CAS 3371-85-5|Voacamine

Introduction：Basic information about CAS 3371-85-5|Voacamine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Voacamine BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Voacamine
CAS Number	3371-85-5	Molecular Weight	704.89700
Density	1.309g/cm3	Boiling Point	/
Molecular Formula	C₄₃H₅₂N₄O₅	Melting Point	223℃
MSDS	/	Flash Point	/

Names

Name	methyl 12-methoxy-13-(17-methoxy-17-oxovobasan-3alpha-yl)ibogamine-18-carboxylate
Synonym	More Synonyms

Voacamine BiologicalActivity

Description	Voacamine, an indole alkaloid, isolated from Voacanga Africana, exhibits potent cannabinoid CB1 receptor antagonistic activity[1]. Voacamine also inhibits P-glycoprotein (P-gp) action in multidrug-resistant tumor cells[1].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Membrane Transporter/Ion Channel >>P-glycoproteinResearch Areas >>Metabolic DiseaseSignaling Pathways >>GPCR/G Protein >>Cannabinoid Receptor
References	[1]. Kitajima M, et al. Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1962-4. [2]. Meschini S, et al. Voacamine, an alkaloid extracted from Peschiera fuchsiaefolia, inhibits P-glycoprotein action in multidrug-resistant tumor cells. Int J Oncol. 2005 Dec;27(6):1597-603.

Description

Voacamine, an indole alkaloid, isolated from Voacanga Africana, exhibits potent cannabinoid CB1 receptor antagonistic activity[1]. Voacamine also inhibits P-glycoprotein (P-gp) action in multidrug-resistant tumor cells[1].

Related Catalog

Research Areas >>CancerSignaling Pathways >>Membrane Transporter/Ion Channel >>P-glycoproteinResearch Areas >>Metabolic DiseaseSignaling Pathways >>GPCR/G Protein >>Cannabinoid Receptor

References

[1]. Kitajima M, et al. Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1962-4.

[2]. Meschini S, et al. Voacamine, an alkaloid extracted from Peschiera fuchsiaefolia, inhibits P-glycoprotein action in multidrug-resistant tumor cells. Int J Oncol. 2005 Dec;27(6):1597-603.

Chemical & Physical Properties

Density	1.309g/cm3
Melting Point	223℃
Molecular Formula	C₄₃H₅₂N₄O₅
Molecular Weight	704.89700
Exact Mass	704.39400
PSA	99.89000
LogP	6.36470
Index of Refraction	1.674
InChIKey	VCMIRXRRQJNZJT-YMUNTWGJSA-N
SMILES	CC=C1CN(C)C2Cc3c([nH]c4ccccc34)C(c3cc4[nH]c5c(c4cc3OC)CCN3CC4CC(CC)C3C5(C(=O)OC)C4)CC1C2C(=O)OC
Storage condition	2-8℃

Synonyms

Dodecandisaeure-monomethylester

methyl hydrogen dodecanedioate

monomethyl-dodecanedioate

epi-Voacamin

methyl ester of 1,12-dodecanedioic acid,dimethyl ester

Dodecanedioic acid monomethyl ester

11MeOCO undec acid

Voacamine

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