Introduction：Basic information about CAS 33421-40-8|2-Amino-5-phenylpyridine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2-Amino-5-phenylpyridine |
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| CAS Number | 33421-40-8 | Molecular Weight | 170.21000 |
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| Density | 1.133g/cm3 | Boiling Point | 323.6ºC at 760mmHg |
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| Molecular Formula | C11H10N2 | Melting Point | 132 °C |
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| MSDS | USA | Flash Point | 175.6ºC |
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Names
| Name | 5-phenylpyridin-2-amine |
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| Synonym | More Synonyms |
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2-Amino-5-phenylpyridine BiologicalActivity
| Description | 2-Amino-5-phenylpyridine is a mutagenic heterocyclic aromatic amine that is formed by pyrolysis of phenylalanine in proteins. 2-Amino-5-phenylpyridine is in broiled sardines and is considered as potentially carcinogenic[1][2]. |
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| Related Catalog | Research Areas >>Cancer |
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| In Vitro | On the other hand, the chemical structure of 5-phenyl-2-pyridinamine (PPA) shows a great resemblance to the aminobiphenyls, another well known class of carcinogenic aromatic amines[2]. |
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| References | [1]. Dooley KL, et al. Comparative carcinogenicity of the food pyrolysis product, 2-amino-5-phenylpyridine, and the known human carcinogen, 4-aminobiphenyl, in the neonatal B6C3F1 mouse. Cancer Lett. 1988 Jul;41(1):99-103. [2]. Stavenuiter JF, et al. Syntheses of 5-phenyl-2-pyridinamine, a possibly carcinogenic pyrolysis product of phenylalanine, and some of its putative metabolites. Carcinogenesis. 1985 Jan;6(1):13-9. |
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Chemical & Physical Properties
| Density | 1.133g/cm3 |
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| Boiling Point | 323.6ºC at 760mmHg |
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| Melting Point | 132 °C |
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| Molecular Formula | C11H10N2 |
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| Molecular Weight | 170.21000 |
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| Flash Point | 175.6ºC |
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| Exact Mass | 170.08400 |
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| PSA | 38.91000 |
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| LogP | 2.91200 |
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| Index of Refraction | 1.625 |
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| InChIKey | OAPVIBHQRYFYSE-UHFFFAOYSA-N |
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| SMILES | Nc1ccc(-c2ccccc2)cn1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- US2145000
- CHEMICAL NAME :
- Pyridine, 2-amino-5-phenyl-
- CAS REGISTRY NUMBER :
- 33421-40-8
- BEILSTEIN REFERENCE NO. :
- 0120219
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C11-H10-N2
- MOLECULAR WEIGHT :
- 170.23
- WISWESSER LINE NOTATION :
- T6NJ BZ FR
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 100 ug/plate
- REFERENCE :
- CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 26,611,1978
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Safety Information
| Hazard Codes | Xn |
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| Risk Phrases | 36/37/38 |
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| Safety Phrases | S26-S36/37/39 |
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| RTECS | US2145000 |
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Synonyms
| 5-phenyl-2-aminopyridine |
| 5-phenyl-pyridin-2-ylamine |
| 5-phenyl-2-pyridinamine |
| 2-Amino-5-phenylpyridine |
| 2-Pyridinamine,5-phenyl |
| 5-Phenylpyridin-2-amine |
| MFCD01692452 |
| Pyridine,2-amino-5-phenyl |
| Phe-P-1 |
