CAS 134234-12-1|CP-101,606
Introduction：Basic information about CAS 134234-12-1|CP-101,606, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | CP-101,606 | ||
|---|---|---|---|
| CAS Number | 134234-12-1 | Molecular Weight | 327.417 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 534.4±50.0 °C at 760 mmHg |
| Molecular Formula | C20H25NO3 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 290.3±28.8 °C |
| Symbol | GHS06, GHS09 | Signal Word | Danger |
Names
| Name | 1-((1S,2S)-1-Hydroxy-1-(4-hydroxyphenyl)propan-2-yl)-4-phenylpiperidin-4-ol |
|---|---|
| Synonym | More Synonyms |
CP-101,606 BiologicalActivity
| Description | Traxoprodil (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC50 of 10 nM. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>iGluRSignaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological Disease |
| Target | IC50: 10 nM (Neuroprotection)[1] |
| In Vivo | Traxoprodil is potent at blocking haloperidol-induced catalepsy and with an ED50 less than 1 mg/kg. Traxoprodil is effective at 1 mg/kg to block NMDA (ip) stimulated cfos induction in mice[1]. Traxoprodil at a dose of 20 and 40 mg/kg exhibits antidepressant activity in the Forced swim test and it is not related to changes in animals’ locomotor activity[2]. Traxoprodil (20 nM i.c.v.) increases the latency to generalized tonic-clonic seizures induced by PTZ (70 mg/kg; i.p.). Traxoprodil (60 mg/kg, p.o.) increases the latency to clonic and generalized seizures, and decreases the total time spent in seizures[3]. |
| Animal Admin | Rats[3] The effect of traxoprodil and SPD on PTZ-induced seizures is investigated by injecting the Adult (90-100 days-old) male Wistar rats (250-300 g) with traxoprodil (0.2, 2 or 20 nM/site), SPD (0.02, 0.2 or 2 nM/site), or with vehicle (0.9% NaCl, 1 μL) 15 min before the administration of PTZ (35 or 70 mg/kg, i.p.)[3]. Mice[2] The Forced swim test is done on male Albino Swiss mice (25-30 g). Traxoprodil (5, 10, 20, 40 mg/kg), imipramine and saline are administered i.p. 60 min before the test. The antidepressant activity is measured[2]. |
| References | [1]. Chenard BL, et al. (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses. J Med Chem. 1995 Aug 4;38(16):3138-45. [2]. Poleszak E, et al. Traxoprodil, a selective antagonist of the NR2B subunit of the NMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice. Metab Brain Dis. 2016 Aug;31(4):803-14. [3]. Naspolini AP, et al. Traxoprodil decreases pentylenetetrazol-induced seizures. Epilepsy Res. 2012 Jun;100(1-2):12-9. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 534.4±50.0 °C at 760 mmHg |
| Molecular Formula | C20H25NO3 |
| Molecular Weight | 327.417 |
| Flash Point | 290.3±28.8 °C |
| Exact Mass | 327.183441 |
| PSA | 63.93000 |
| LogP | 1.75 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.626 |
| InChIKey | QEMSVZNTSXPFJA-HNAYVOBHSA-N |
| SMILES | CC(C(O)c1ccc(O)cc1)N1CCC(O)(c2ccccc2)CC1 |
| Storage condition | 2-8℃ |
Safety Information
| Symbol | GHS06, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H319-H400 |
| Precautionary Statements | P273-P301 + P310-P305 + P351 + P338 |
| RIDADR | UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all |
Synonyms
| 1-[(1S,2S)-1-Hydroxy-1-(4-hydroxyphenyl)-2-propanyl]-4-phenyl-4-piperidinol |
| 1-((1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl)-4-phenylpiperidin-4-ol |
| 1-[(1S,2S)-2-Hydroxy-2-(4-hydroxy-phenyl)-1-methyl-ethyl]-4-phenyl-piperidin-4-ol |
| traxoprodil |
| CP 101606 |
| 1-Piperidineethanol, 4-hydroxy-α-(4-hydroxyphenyl)-β-methyl-4-phenyl-, (αS,βS)- |
| (1S,2S)-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol |
