CAS 138579-66-5|Galanin (1-13)-Substance P (5-11) amide
| Common Name | Galanin (1-13)-Substance P (5-11) amide | ||
|---|---|---|---|
| CAS Number | 138579-66-5 | Molecular Weight | 2199.53000 |
| Density | / | Boiling Point | / |
| Molecular Formula | C104H151N25O26S | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | Galantide |
|---|---|
| Synonym | More Synonyms |
Galanin (1-13)-Substance P (5-11) amide BiologicalActivity
| Description | Galantide is a reversible and non-specific galanin receptor antagonist. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Neuropeptide Y ReceptorResearch Areas >>Inflammation/ImmunologyResearch Areas >>Metabolic DiseaseResearch Areas >>Neurological DiseasePeptides |
| In Vitro | Galantide dose dependently (IC50=1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets. The antagonist is also found to displace 125I-monoiodo-[TyrZ6]galanin from membranes of the insulin producing Rin m 5F cells with an IC50 value of less than 0.1 nM[1]. |
| In Vivo | Intracerebroventricular injection of galanin (5 micrograms/rat) inhibited sexual behavior in experienced male rats--without producing any other locomotor or behavioral deficit-, injection of the galanin antagonist, galantide, by the same route (1 or 2 micrograms/rat) stimulated sexual behavior (improving arousal, motivation and performance indexes) and antagonized the effect of galanin[2]. Galantide ameliorates mild acute pancreatitis (AP). Galantide significantly reduces AP-induced hyperenzymemia by 41–49%[3]. Galantide has been found to improve social memory in 'socialrecognition' test when i.c.v. administered at doses varying from 6-6000 nM[4]. |
| Animal Admin | Rats: Galantide is dissolved in 0.9% NaCl. The i.c.v. injection is given to the resident rat immediately after removal of the juvenile, at the end of the first encounter. Control rats receive an equal volume (4 µL) of saline by the same route, at the same infusion rate (1 µL/20 s) and at the same time. A minimum of 10 adult rats are used for each dose level[4]. Mice: Galantide stock solution is prepared in 0.01% bovine serum albumin in saline. The mice are allocated to 7 groups: Mice administered the vehicle for injection (saline alone), mice administered only caerulein (AP alone), mice administered only galantide (GT alone) or feG (feG alone), mice administered caerulein and galantide (AP+GT) or caerulein and feG (AP+feG) and finally mice that are administered with caerulein, galantide and feG (AP+GT+feG). On the day prior to the AP induction, a blood sample is collected to measure the basal plasma amylase activity[3]. |
| References | [1]. Lindskog S, et al. The novel high-affinity antagonist, galantide, blocks the galanin-mediatedinhibition of glucose-induced insulin secretion. Eur J Pharmacol. 1992 Jan 14;210(2):183-8. [2]. Benelli A, et al. Galantide stimulates sexual behaviour in male rats. Eur J Pharmacol. 1994 Aug 1;260(2-3):279-82. [3]. Barreto SG, et al. The efficacy of combining feG and galantide in mild caerulein-induced acutepancreatitis in mice. Peptides. 2010 Jun;31(6):1076-82. [4]. Arletti R, et al. Galantide improves social memory in rats. Pharmacol Res. 1997 Apr;35(4):317-9. |
Chemical & Physical Properties
| Molecular Formula | C104H151N25O26S |
|---|---|
| Molecular Weight | 2199.53000 |
| Exact Mass | 2198.10000 |
| PSA | 844.27000 |
| LogP | 4.41220 |
| InChIKey | TZOJVPDIYKRJSM-GKPUQKAJSA-N |
| SMILES | CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)CNC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)CNC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)CN)C(C)O)C(N)=O |
| Storage condition | -20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xn |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3.0 |
Articles56
More Articles| The GTP- and Phospholipid-Binding Protein TTD14 Regulates Trafficking of the TRPL Ion Channel in Drosophila Photoreceptor Cells. PLoS Genet. 11(10) , e1005578, (2015) Recycling of signaling proteins is a common phenomenon in diverse signaling pathways. In photoreceptors of Drosophila, light absorption by rhodopsin triggers a phospholipase Cβ-mediated opening of the... | |
| Modulation of the mitochondrial voltage dependent anion channel (VDAC) by curcumin. Biochim. Biophys. Acta 1848(1 Pt A) , 151-8, (2015) Voltage dependent anion channel (VDAC) of mitochondria plays a crucial role in apoptosis. Human VDAC-1, reconstituted in planar lipid bilayer showed reduced conductance when treated with curcumin. Cur... | |
| A crayfish molar tooth protein with putative mineralized exoskeletal chitinous matrix properties. J. Exp. Biol. 218 , 3487-98, (2015) Some crustaceans possess exoskeletons that are reinforced with calcium carbonate. In the crayfish Cherax quadricarinatus, the molar tooth, which is part of the mandibular exoskeleton, contains an unus... |
Synonyms
| M15 |
| L-Methioninamide,glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl |
