CAS 82196-88-1|Chrysomycin A
Introduction：Basic information about CAS 82196-88-1|Chrysomycin A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Chrysomycin A | ||
|---|---|---|---|
| CAS Number | 82196-88-1 | Molecular Weight | 508.517 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 799.7±60.0 °C at 760 mmHg |
| Molecular Formula | C28H28O9 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 269.6±26.4 °C |
Names
| Name | Chrysomycin A |
|---|---|
| Synonym | More Synonyms |
Chrysomycin A BiologicalActivity
| Description | Chrysomycin A (Chr-A), an antibiotic, can be obtained from Streptomyces. Chrysomycin A exhibits antitumor and anti-tuberculous and MRSA activities. As for glioblastoma, Chrysomycin A inhibits the proliferation, migration, and invasion of cancer cells through the Akt/GSK-3β/β-catenin signaling pathway[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Stem Cell/Wnt >>GSK-3Research Areas >>CancerResearch Areas >>InfectionSignaling Pathways >>PI3K/Akt/mTOR >>AktSignaling Pathways >>Apoptosis >>c-MycSignaling Pathways >>PI3K/Akt/mTOR >>GSK-3Signaling Pathways >>Anti-infection >>Bacterial |
| In Vitro | Chrysomycin A (0.2-1.8 μM; 48 h) 具有抗胶质母细胞瘤作用，抑制 U251 和 U87-MG 人胶质母细胞瘤的细胞活力，以及迁移和侵袭[1]。 Chrysomycin A (0.2-1.8 μM; 48 h) 抑制 U251 和 U87-MG 细胞中 Akt/GSK-3β/β-Catenin 信号通路[1]。 Cell Viability Assay[1] Cell Line: U251 and U87-MG human glioblastoma Concentration: 0.2, 0.4 and 0.8 μM for U251; 0.2, 0.6 and 1.8 μM for U87-MG Incubation Time: 48 hours Result: Inhibited U251 and U87-MG with 0.475 μM and 1.77 μM, respectively. Western Blot Analysis[1] Cell Line: U251 and U87-MG human glioblastoma Concentration: 0.2, 0.4 and 0.8 μM for U251; 0.2, 0.6 and 1.8 μM for U87-MG Incubation Time: 48 hours Result: Significantly downregulated the expression of slug and MMP2. Significantly decreased the protein expression of PI3K-p85, p-PI3K-p85, Akt and p-Akt, as well as c-Myc, cyclin D1. |
| References | [1]. Liu DN, et al. Chrysomycin A Inhibits the Proliferation, Migration and Invasion of U251 and U87-MG Glioblastoma Cells to Exert Its Anti-Cancer Effects. Molecules. 2022 Sep 20;27(19):6148. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 799.7±60.0 °C at 760 mmHg |
| Molecular Formula | C28H28O9 |
| Molecular Weight | 508.517 |
| Flash Point | 269.6±26.4 °C |
| Exact Mass | 508.173340 |
| PSA | 138.82000 |
| LogP | 5.08 |
| Appearance of Characters | solid |
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
| Index of Refraction | 1.679 |
| InChIKey | OMDANBMKOUVKAG-WZNMFJNZSA-N |
| SMILES | C=Cc1cc(OC)c2c(c1)c(=O)oc1c2cc(OC)c2c(O)ccc(C3OC(C)C(O)C(C)(O)C3O)c21 |
| Storage condition | 2-8°C |
| Water Solubility | DMF: soluble |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles6
More Articles| Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis. Nat. Prod. Rep. 29(2) , 264-325, (2012) Covering: 1997 to 2010. The angucycline group is the largest group of type II PKS-engineered natural products, rich in biological activities and chemical scaffolds. This stimulated synthetic creativit... | |
| The chemistry of the antibiotics chrysomycin A and B. Antitumor activity of chrysomycin A. J. Antibiot. 35(9) , 1194-201, (1982) The yellow antibiotic chrysomycin, isolated in crystalline form in 1955, is found to consist of two closely related components, a major one, chrysomycin A, and a minor one, chrysomycin B. They differ ... | |
| Antitumor activity of chrysomycins M and V. J. Antibiot. 42(9) , 1446-8, (1989) |
Synonyms
| Chrysomycin V |
| 6H-Benzo(d)naphtho(1,2-b)pyran-6-one, 4-(6-deoxy-3-C-methyl-β-gulopyranosyl)-8-ethenyl-1-hydroxy-10,12-dimethoxy- |
| L-Glucitol, 2,6-anhydro-1-deoxy-6-C-(8-ethenyl-1-hydroxy-10,12-dimethoxy-6-oxo-6H-benzo[d]naphtho[1,2-b]pyran-4-yl)-4-C-methyl-, (6S)- |
| Virenomycin V |
| (6S)-2,6-Anhydro-1-deoxy-6-(1-hydroxy-10,12-dimethoxy-6-oxo-8-vinyl-6H-dibenzo[c,h]chromen-4-yl)-4-C-methyl-L-glucitol |
