CAS 58069-83-3|Urea-13C,15N2

Introduction：Basic information about CAS 58069-83-3|Urea-13C,15N2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Urea-13C,15N2 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Urea-13C,15N2
CAS Number	58069-83-3	Molecular Weight	63.03470
Density	1.212g/cm3	Boiling Point	/
Molecular Formula	CH₄N₂O	Melting Point	132-135ºC(lit.)
MSDS	USA	Flash Point	/

Names

Name	urea (13c, 15n2)
Synonym	More Synonyms

Urea-13C,15N2 BiologicalActivity

Description	Urea-13C,15N2 is the 13C and 15N labeled Urea[1]. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Bennion BJ, et al. The molecular basis for the chemical denaturation of proteins by urea. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5142-7. [3]. Pan M, et al. Urea: a comprehensive review of the clinical literature. Dermatol Online J. 2013 Nov 1519(11):20392.Wang H, et al. Urea. Subcell Biochem. 201473:7-29. [4]. Wang H, et al. Urea. Subcell Biochem. 201473:7-29.

Description

Urea-13C,15N2 is the 13C and 15N labeled Urea[1]. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Bennion BJ, et al. The molecular basis for the chemical denaturation of proteins by urea. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5142-7.

[3]. Pan M, et al. Urea: a comprehensive review of the clinical literature. Dermatol Online J. 2013 Nov 1519(11):20392.Wang H, et al. Urea. Subcell Biochem. 201473:7-29.

[4]. Wang H, et al. Urea. Subcell Biochem. 201473:7-29.

Chemical & Physical Properties

Density	1.212g/cm3
Melting Point	132-135ºC(lit.)
Molecular Formula	CH₄N₂O
Molecular Weight	63.03470
Exact Mass	63.02980
PSA	69.11000
LogP	0.42440
Index of Refraction	1.468
InChIKey	XSQUKJJJFZCRTK-VMIGTVKRSA-N
SMILES	NC(N)=O

Safety Information

Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	Xn
Risk Phrases	36/37/38-40
Safety Phrases	22-26-36
RIDADR	NONH for all modes of transport

Synonyms

urea<15N2-13C>

<13C,15N2>urea

MFCD00145506

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