CAS 255906-59-3|VK3-OCH3

Introduction：Basic information about CAS 255906-59-3|VK3-OCH3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameVK3-OCH3
CAS Number255906-59-3Molecular Weight262.32400
Density/Boiling Point/
Molecular FormulaC14H14O3SMelting Point/
MSDSChineseUSAFlash Point/
Symbol
GHS09		Signal WordWarning

Names

Name2-[(2-Methoxy)ethylthio]-3-methyl-1,4-naphthoquinone
SynonymMore Synonyms

VK3-OCH3 BiologicalActivity

DescriptionVK3-OCH3 is a potent antitumor agent. VK3-OCH3 shows cytotoxicity for neuroblastoma cell lines and low cytotoxicity for normal cell lines. VK3-OCH3 induces apoptosis and cell cycle arrest at G2/M phase in IMR-32 cells. VK3-OCH3 shows antitumor activity[1].
Related CatalogResearch Areas >>CancerSignaling Pathways >>Others >>Others
In VitroVK3-OCH3 (compound 5) shows cytotoxicity with IC50s of 2.43, 1.55, 10.69, 3.45, 26.24, 87.11 µM for IMR-32, LA-N-1, NB-39, SK-N-SH, HUVEC, HDF cells, respectively[1]. VK3-OCH3 (1, 3, 10 µM) induces apoptosis and cell cycle arrest at G2/M phase in IMR-32 cells[1]. VK3-OCH3 (0-48 h) increases the expression of HO-1 in 8~24 h, and Caveolin-1 in 48 h in IMR-32 and LA-N-1 cells[1]. VK3-OCH3 (0-48 h) increases the expression of phospho-p38-MAPK and decreases the expression of p21 and clusterin[1].
References

[1]. Kitano T, et al. Vitamin K3 analogs induce selective tumor cytotoxicity in neuroblastoma. Biol Pharm Bull. 2012;35(4):617-23.

Chemical & Physical Properties

Molecular FormulaC14H14O3S
Molecular Weight262.32400
Exact Mass262.06600
PSA68.67000
LogP2.71920
InChIKeyJTCRCMIBIBLUOK-UHFFFAOYSA-N
SMILESCOCCSC1=C(C)C(=O)c2ccccc2C1=O
Storage condition2-8°C

Safety Information

Symbol
GHS09
Signal WordWarning
Hazard StatementsH400
Precautionary StatementsP273
RIDADRUN 3077 9 / PGIII
HS Code2930909090

Customs

HS Code2930909090
Summary2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Synonyms

2-[(2-Methoxyethyl)thio]-3-methyl-1,4-napthalenedione
2-(2-methoxyethylsulfanyl)-3-methylnaphthalene-1,4-dione
CAS 931581-17-8|2-Benzimidazolethiol-d4
CAS 52055-22-8|2-(5-Methoxy-1H-indol-3-yl)-2-oxoacetamide
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