Introduction：Basic information about CAS 61563-24-4|Isoquinoline, 7,9-dichloro-1,2,3,4-tetrahydro-, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Isoquinoline, 7,9-dichloro-1,2,3,4-tetrahydro- |
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| CAS Number | 61563-24-4 | Molecular Weight | 202.08000 |
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| Density | 1.293g/cm3 | Boiling Point | 310.7ºC at 760 mmHg |
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| Molecular Formula | C9H9Cl2N | Melting Point | / |
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| MSDS | / | Flash Point | 141.7ºC |
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Names
| Name | 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (compound 11), a tetrahydroisoquinoline (THIQ) derivative, is a selective phenylethanolamine N-methyltransferase (PNMT) inhibitor with a Ki value of 0.3 μM. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline can be used in research on psychiatric disorders related to Alzheimer's disease and Parkinson's disease[1]. |
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| Related Catalog | Research Areas >>Neurological Disease |
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| In Vivo | 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (SKF-64139) (i.p., 40 mg/kg, once daily, 3 days) has an important role in the regulation of blood pressure and changes in adrenal catecholamine levels in rats[2]. Animal Model: Male spontaneously hypertensive (SHR) and their age-paired normotensive Wistar-Kyoto (WKY) rats[2] Dosage: 40 mg/kg Administration: i.p.; once daily; 3 days Result: Caused a decrease in blood pressure in SHR rats but no effect on blood pressure in WKY rats. Caused a decrease in hypothalamic epinephrine (Epi) levels, norepinephrine (NE) levels and raised dopamine (DA) levels in both SHR and WKY rats. |
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| References | [1]. Pramod C Nair, et al. Using Theory to Reconcile Experiment: The Structural and Thermodynamic Basis of Ligand Recognition by Phenylethanolamine N-Methyltransferase (PNMT). J Chem Theory Comput. 2011 May 10;7(5):1458-68. [2]. N Y Liang, et al. Inhibitors of phenylethanolamine-N-methyltransferase. 2. Comparison of nonaromatic analogs of phenylethanolamines, 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline (SKF-64139) and 2,3-dichloro-alpha-methylbenzylamine: effects on rat brain and adrenal catecholamine content and blood pressure. J Pharmacol Exp Ther. 1982 Nov;223(2):382-7. |
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Chemical & Physical Properties
| Density | 1.293g/cm3 |
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| Boiling Point | 310.7ºC at 760 mmHg |
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| Molecular Formula | C9H9Cl2N |
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| Molecular Weight | 202.08000 |
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| Flash Point | 141.7ºC |
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| Exact Mass | 201.01100 |
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| PSA | 12.03000 |
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| LogP | 2.96790 |
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| Index of Refraction | 1.574 |
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| InChIKey | WFPUBEDBBOGGIQ-UHFFFAOYSA-N |
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| SMILES | Clc1ccc2c(c1Cl)CNCC2 |
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Safety Information
Customs
| HS Code | 2933499090 |
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| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 7,8-Dichlor-1,2,3,4-tetrahydroisochinolin |
| 1yz3 |
| 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline |
| SK&SKA |
