Introduction：Basic information about CAS 165682-93-9|O4I2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | O4I2 |
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| CAS Number | 165682-93-9 | Molecular Weight | 282.746 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 408.1±51.0 °C at 760 mmHg |
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| Molecular Formula | C12H11ClN2O2S | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 200.6±30.4 °C |
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Names
| Name | ethyl 2-(4-chloroanilino)-1,3-thiazole-4-carboxylate |
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| Synonym | More Synonyms |
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O4I2 BiologicalActivity
| Description | O4I2 is a potent Oct3/4 inducer in various human cell lines including human fibroblasts.Target: Oct3/4O4I2 activates Oct3/4 in HEK293 and embryonal NCCIT cells, and also in Oct-deficient HeLa and terminally differentiated human fibroblasts. O4I2 activates also other pluripotencyassociatedgenes such as Lin28 and Nanog in a drug-like manner. O4I2 shows high activity in enforcing Oct3/4 expression. O4I2 activates Oct3/4 on the transcriptional and translational level in human fibroblasts. O4I2 promotes the expression of pluripotency-associated genes as analyzed by qRT-PCR in human neonatal foreskin fibroblasts (HFFs). O4I2 markedly stimulates Oct3/4 even at 5 μM after 72 h treatment on the translational level. |
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| Related Catalog | Signaling Pathways >>Stem Cell/Wnt >>Oct3/4Research Areas >>Others |
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| References | [1]. Cheng X, et al. Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and Derivatives Are Potent Inducers of Oct3/4. J Med Chem. 2015 Aug 13;58(15):5742-5750. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 408.1±51.0 °C at 760 mmHg |
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| Molecular Formula | C12H11ClN2O2S |
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| Molecular Weight | 282.746 |
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| Flash Point | 200.6±30.4 °C |
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| Exact Mass | 282.022980 |
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| PSA | 79.46000 |
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| LogP | 3.83 |
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| Appearance of Characters | light yellow solid |
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| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
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| Index of Refraction | 1.637 |
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| InChIKey | ULUBAPWNHROTEU-UHFFFAOYSA-N |
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| SMILES | CCOC(=O)c1csc(Nc2ccc(Cl)cc2)n1 |
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| Storage condition | -20℃ |
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Safety Information
| RIDADR | NONH for all modes of transport |
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| HS Code | 2934100090 |
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Customs
| HS Code | 2934100090 |
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| Summary | 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
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Synonyms
| Ethyl 2-[(4-chlorophenyl)amino]-1,3-thiazole-4-carboxylate |
| ETHYL 2-(4-CHLOROPHENYLAMINO)-4-THIAZOLECARBOXYLATE |
| 4-Thiazolecarboxylic acid, 2-[(4-chlorophenyl)amino]-, ethyl ester |
| O4I2 |
