Introduction：Basic information about CAS 13850-16-3|Tormentic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tormentic acid |
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| CAS Number | 13850-16-3 | Molecular Weight | 488.699 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 602.7±55.0 °C at 760 mmHg |
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| Molecular Formula | C30H48O5 | Melting Point | / |
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| MSDS | / | Flash Point | 332.3±28.0 °C |
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Names
| Name | (1R,2R,4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-1,10,11-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid |
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| Synonym | More Synonyms |
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Tormentic acid BiologicalActivity
| Description | Tormentic acid, a triterpene isolated from Rosa rugosa, exerts anti-inflammatory, antihyperlipidemic, and anti-atherogenic properties[1][2]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
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| In Vitro | Tormentic acid inhibits LPS-induced iNOS, COX-2, and TNF-α expression through inactivation of the nuclear factor-κb pathway in RAW 264.7 macrophages[1]. Tormentic acid suppresses high-fat diet-induced diabetes and hyperlipidemia by glucose transporter 4 and AMP-activated protein kinase phosphorylation[2]. |
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| References | [1]. An HJ, et al. Tormentic acid, a triterpenoid saponin, isolated from Rosa rugosa, inhibited LPS-induced iNOS, COX-2, and TNF-α expression through inactivation of the nuclear factor-κb pathway in RAW 264.7 macrophages. Int Immunopharmacol. 2011 Apr;11(4):504-10. [2]. Wu JB, et al. Tormentic acid, a major component of suspension cells of Eriobotrya japonica, suppresses high-fat diet-induced diabetes and hyperlipidemia by glucose transporter 4 and AMP-activated protein kinase phosphorylation. J Agric Food Chem. 2014 Nov 5;62(44):10717-26. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 602.7±55.0 °C at 760 mmHg |
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| Molecular Formula | C30H48O5 |
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| Molecular Weight | 488.699 |
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| Flash Point | 332.3±28.0 °C |
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| Exact Mass | 488.350189 |
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| PSA | 97.99000 |
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| LogP | 6.21 |
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| Vapour Pressure | 0.0±3.9 mmHg at 25°C |
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| Index of Refraction | 1.580 |
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| InChIKey | OXVUXGFZHDKYLS-BLIWDXROSA-N |
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| SMILES | CC1CCC2(C(=O)O)CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(C)C5CCC43C)C2C1(C)O |
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Safety Information
Synonyms
| Urs-12-en-28-oic acid, 2,3,19-trihydroxy-, (2α,3β)- |
| Jacarandic acid |
| tomentic acid |
| Tormentic acid |
| (2α,3β)-2,3,19-Trihydroxyurs-12-en-28-oic acid |
| Euscaphic acid |
| 2,3,19-trihydroxyurs-12-en-28-oic acid |
