CAS 611-23-4|1-Methyl-2-nitrosobenzene

CHEMICAL IDENTIFICATION

RTECS NUMBER :

XT3400000

CHEMICAL NAME :

Toluene, o-nitroso-

CAS REGISTRY NUMBER :

611-23-4

BEILSTEIN REFERENCE NO. :

1927295

LAST UPDATED :

199709

DATA ITEMS CITED :

2

MOLECULAR FORMULA :

C7-H7-N-O

MOLECULAR WEIGHT :

121.15

WISWESSER LINE NOTATION :

ONR B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

103 gm/kg/73W-C

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

MUTATION DATA

TYPE OF TEST :

Mutation in microorganisms

TEST SYSTEM :

Bacteria - Salmonella typhimurium

DOSE/DURATION :

1 umol/plate

REFERENCE :

IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 25,618,1987

Arch. Biochem. Biophys. 436(2) , 265-75, (2005)

The inactivation of cytochrome P450 enzymes by cyclopropylamines has been attributed to a mechanism involving initial one-electron oxidation at nitrogen followed by scission of the cyclopropane ring l...

Arch. Biochem. Biophys. 372(1) , 97-106, (1999)

Mechanisms of DNA damage by metabolites of carcinogenic o-toluidine in the presence of metals were investigated by the DNA sequencing technique using (32)P-labeled human DNA fragments. 4-Amino-3-methy...

Cancer Lett. 16(1) , 103-8, (1982)

o-Toluidine hydrochloride and one of its metabolites, o-nitrosotoluene, were administered in the diet (0.028 mol/kg diet) to 2 groups of 30 male F-344 rats for 72 weeks. o-Nitrosotoluene induced signi...