CAS 652-67-5|Isosorbide

Introduction：Basic information about CAS 652-67-5|Isosorbide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Isosorbide BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	Isosorbide
CAS Number	652-67-5	Molecular Weight	146.141
Density	1.5±0.1 g/cm3	Boiling Point	372.1±42.0 °C at 760 mmHg
Molecular Formula	C₆H₁₀O₄	Melting Point	60-63 °C(lit.)
MSDS	Chinese	Flash Point	178.8±27.9 °C

Names

Name	Isosorbide
Synonym	More Synonyms

Isosorbide BiologicalActivity

Description	Isosorbide is used as a diuretic used mainly to treat hydrocephalus and is also used to treat glaucoma.
Related Catalog	Signaling Pathways >>Autophagy >>AutophagyResearch Areas >>Cardiovascular Disease

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	372.1±42.0 °C at 760 mmHg
Melting Point	60-63 °C(lit.)
Molecular Formula	C₆H₁₀O₄
Molecular Weight	146.141
Flash Point	178.8±27.9 °C
Exact Mass	146.057907
PSA	58.92000
LogP	-1.75
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.562
InChIKey	KLDXJTOLSGUMSJ-JGWLITMVSA-N
SMILES	OC1COC2C(O)COC12

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ4380000

CAS REGISTRY NUMBER :: 652-67-5

BEILSTEIN REFERENCE NO. :: 0080510

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C6-H10-O4

MOLECULAR WEIGHT :: 146.16

WISWESSER LINE NOTATION :: L44TJ BQ EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 24150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,15,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 64(4),158S,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 289 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,187,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,71,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6870 mg/kg

TOXIC EFFECTS :: Brain and Coverings - changes in cerebral spinal fluid

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,15,1969

Safety Information

Hazard Codes	Xi
Risk Phrases	R22
Safety Phrases	S24/25
WGK Germany	2
RTECS	LZ4380000
HS Code	2932999099

Customs

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

(3R,3aR,6S,6aR)-hexahydrofuro[3,2-b]furane-3,6-diol

Isosorbid

EINECS 211-492-3

D-Glucitol, 1,4:3,6-dianhydro-

D-Isosorbide

dianhydro-D-sorbitol

Isosorbide

dianhydro-D-glucitol

L-Glucitol, 1,4:3,6-dianhydro-

hydronol

1,4:3,6-Dianhydro-D-glucitol

D-1,4:3,6-Dianhydroglucitol

MFCD00064827

at101

1,4:3,6-dianhydrogluticol

IsMotic

(3R,3aR,6S,6aR)-hexahydrofuro[3,2-b]furan-3,6-diol

isobide

1,4:3,6-dianhydro-D-sorbitol

devicoran

1,4:3,6-Dianhydro-L-glucitol

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