Introduction：Basic information about CAS 252881-74-6|NH2-PEG3-C2-Boc, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | NH2-PEG3-C2-Boc |
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| CAS Number | 252881-74-6 | Molecular Weight | 277.35700 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C13H27NO5 | Melting Point | / |
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| MSDS | / | Flash Point | 169.7ºC |
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Names
| Name | tert-butyl 3-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]propanoate |
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| Synonym | More Synonyms |
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NH2-PEG3-C2-Boc BiologicalActivity
| Description | NH2-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | PEGs |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1] |
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| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
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Chemical & Physical Properties
| Molecular Formula | C13H27NO5 |
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| Molecular Weight | 277.35700 |
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| Flash Point | 169.7ºC |
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| Exact Mass | 277.18900 |
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| PSA | 80.01000 |
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| LogP | 1.42700 |
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| InChIKey | CWFSAZJIJBTKRC-UHFFFAOYSA-N |
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| SMILES | CC(C)(C)OC(=O)CCOCCOCCOCCN |
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Safety Information
| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | 36/37/38 |
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| Safety Phrases | 26 |
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| HS Code | 2922509090 |
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Customs
| HS Code | 2922509090 |
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| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| H2N-OEG-CO2tBu |
| tert-butyl 3-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}propanoate |
| tert-Butyl 3-[2-(2-(2-aminoethoxy)ethoxy)ethoxy]propionate |
| NH2(CH2CH2O)3CH2CH2COOt-Bu |
| 12-amino-4,7,10-trioxadodecanoic acid tert-butyl ester |
| Amin PEG3-t-butyl ester |
| tert-butyl 12-amino-4,7,10-trioxododecanoate |
| tert-Butyl 12-amino-4,7,10-trioxadodecanoate |
| 3-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]propionic acid tert-butyl ester |
