CAS 253863-00-2|L-778123 (hydrochloride)

Introduction：Basic information about CAS 253863-00-2|L-778123 (hydrochloride), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. L-778123 (hydrochloride) BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	L-778123 (hydrochloride)
CAS Number	253863-00-2	Molecular Weight	442.341
Density	/	Boiling Point	698.9ºC at 760 mmHg
Molecular Formula	C₂₂H₂₁Cl₂N₅O	Melting Point	/
MSDS	/	Flash Point	376.5ºC

Names

Name	4-[[5-[[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl]imidazol-1-yl]methyl]benzonitrile,hydrochloride
Synonym	More Synonyms

L-778123 (hydrochloride) BiologicalActivity

Description	L-778123 hydrochloride is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination.IC50 value: 2 nM [1]Target: FPTasein vitro: L-778123 can completely inhibit Ki-Ras prenylation. [1] L-778123 as a farnesyltransferase inhibitor can have a good cytotoxic activity as a classic anti-cancer agent. [2]in vivo: In the dog model, L-778123 inhibits HDJ2 prenylation and produces measurable, albeit slight (5%), levels of unprenylatedRap1A in PBMCs. [1]
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>Farnesyl TransferaseResearch Areas >>Cancer
References	[1]. Lobell RB, et al. Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I. Mol Cancer Ther. 2002 Jul;1(9):747-758. [2]. Ghasemi S, et al. Comparison of Cytotoxic Activity of L778123 as a Farnesyltranferase Inhibitor and Doxorubicin against A549 and HT-29 Cell Lines. Adv Pharm Bull. 2013;3(1):73-77.

Description

L-778123 hydrochloride is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination.IC50 value: 2 nM [1]Target: FPTasein vitro: L-778123 can completely inhibit Ki-Ras prenylation. [1] L-778123 as a farnesyltransferase inhibitor can have a good cytotoxic activity as a classic anti-cancer agent. [2]in vivo: In the dog model, L-778123 inhibits HDJ2 prenylation and produces measurable, albeit slight (5%), levels of unprenylatedRap1A in PBMCs. [1]

Related Catalog

Signaling Pathways >>Metabolic Enzyme/Protease >>Farnesyl TransferaseResearch Areas >>Cancer

References

[1]. Lobell RB, et al. Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I. Mol Cancer Ther. 2002 Jul;1(9):747-758.

[2]. Ghasemi S, et al. Comparison of Cytotoxic Activity of L778123 as a Farnesyltranferase Inhibitor and Doxorubicin against A549 and HT-29 Cell Lines. Adv Pharm Bull. 2013;3(1):73-77.

Chemical & Physical Properties

Boiling Point	698.9ºC at 760 mmHg
Molecular Formula	C₂₂H₂₁Cl₂N₅O
Molecular Weight	442.341
Flash Point	376.5ºC
Exact Mass	441.112305
PSA	65.16000
LogP	4.11018
Vapour Pressure	2.22E-19mmHg at 25°C
InChIKey	YNBSQYGTJLIPJS-UHFFFAOYSA-N
SMILES	Cl.N#Cc1ccc(Cn2cncc2CN2CCN(c3cccc(Cl)c3)C(=O)C2)cc1
Storage condition	2-8℃

Synonyms

Benzonitrile, 4-[[5-[[4-(3-chlorophenyl)-3-oxo-1-piperazinyl]methyl]-1H-imidazol-1-yl]methyl]-, hydrochloride (1:1)

4-((5-((4-(3-Chlorophenyl)-3-oxo-1-piperazinyl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile hydrochloride

4-[(5-{[4-(3-Chlorophenyl)-3-oxo-1-piperazinyl]methyl}-1H-imidazol-1-yl)methyl]benzonitrile hydrochloride (1:1)

Benzonitrile,4-((5-((4-(3-chlorophenyl)-3-oxo-1-piperazinyl)methyl)-1H-imidazol-1-yl)methyl)-,monohydrochloride

4-[(5-{[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl}-1h-imidazol-1-yl)methyl]benzonitrile hydrochloride(1:1)

L 778123

L-778123

L-778123 HCl

L-778123 (hydrochloride)

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