CAS 1352608-82-2|Vactosertib (TEW-7197)
Introduction：Basic information about CAS 1352608-82-2|Vactosertib (TEW-7197), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Vactosertib (TEW-7197) | ||
|---|---|---|---|
| CAS Number | 1352608-82-2 | Molecular Weight | 399.424 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C22H18FN7 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | 1H-Imidazole-2-methanamine, N-(2-fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl |
|---|---|
| Synonym | More Synonyms |
Vactosertib (TEW-7197) BiologicalActivity
| Description | Vactosertib (EW-7197) is an ATP-competitive inhibitor of ALK5 with an IC50 of 12.9 nM. It also inhibits ALK2 and ALK4 at nanomolar concentrations. |
|---|---|
| Related Catalog | Signaling Pathways >>TGF-beta/Smad >>TGF-β ReceptorResearch Areas >>Cancer |
| Target | IC50: 12.9 nM (TRPV4)[1] |
| References | [1]. Jin CH et al. Discovery of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): a highly potent, selective, and orally bioavailable inhibitor of TGF-β type I receptor kinase as cancer immunotherapeutic/antifibrotic agent. J Med Chem, 2014 May 22, 57(10):4213-38. [2]. Son JY et al. EW-7197, a novel ALK-5 kinase inhibitor, potently inhibits breast to lung metastasis, 2014 Jul, 13(7):1704-16. [3]. Yoon JH et al. Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4,thereby derepressing eomesodermin in cytotoxic T lymphocytes. EMBO Mol Med, 2013 Nov, 5(11):1720-39. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C22H18FN7 |
| Molecular Weight | 399.424 |
| Exact Mass | 399.160767 |
| PSA | 83.79000 |
| LogP | 3.19 |
| Index of Refraction | 1.725 |
| InChIKey | FJCDSQATIJKQKA-UHFFFAOYSA-N |
| SMILES | Cc1cccc(-c2[nH]c(CNc3ccccc3F)nc2-c2ccc3ncnn3c2)n1 |
| Storage condition | -20℃ |
Synonyms
| 2-Fluoro-N-{[4-(6-methyl-2-pyridinyl)-5-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-imidazol-2-yl]methyl}aniline |
| 1H-Imidazole-2-methanamine, N-(2-fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl- |
| EW-7197 |
| N-[[4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl]methyl]-2-fluoroaniline |
| TEW-7197 |
