Introduction：Basic information about CAS 16960-16-0|Adrenocorticotropic Hormone Fragment 1-24 human, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Adrenocorticotropic Hormone Fragment 1-24 human |
|---|
| CAS Number | 16960-16-0 | Molecular Weight | 2933.437 |
|---|
| Density | 1.5±0.1 g/cm3 | Boiling Point | / |
|---|
| Molecular Formula | C136H210N40O31S | Melting Point | / |
|---|
| MSDS | USA | Flash Point | / |
|---|
Names
| Name | Cosyntropin |
|---|
| Synonym | More Synonyms |
|---|
BiologicalActivity
| Description | Tetracosactide (INN) is an analogue of adrenocorticotrophic hormone (ACTH), with the biological activity of stimulating production of corticosteroids in the adrenal cortex. Sequence: Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro. |
|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>CancerPeptides |
|---|
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|
| Molecular Formula | C136H210N40O31S |
|---|
| Molecular Weight | 2933.437 |
|---|
| Exact Mass | 2931.580566 |
|---|
| PSA | 1184.02000 |
|---|
| LogP | -3.27 |
|---|
| Index of Refraction | 1.681 |
|---|
| InChIKey | ZOEFCCMDUURGSE-SQKVDDBVSA-N |
|---|
| SMILES | CSCCC(NC(=O)C(CO)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(N)CO)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCC(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)N1CCCC1C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(Cc1ccc(O)cc1)C(=O)N1CCCC1C(=O)O)C(C)C)C(C)C)C(C)C |
|---|
| Storage condition | −20°C |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- GM7915000
- CHEMICAL NAME :
- alpha(sup 1-24)-Corticotropin
- CAS REGISTRY NUMBER :
- 16960-16-0
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C136-H210-N40-O31-S
- MOLECULAR WEIGHT :
- 2933.92
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 5 ug/kg
- TOXIC EFFECTS :
- Cardiac - change in rate Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 237,879,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4549 No. of Facilities: 24 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1071 (estimated) No. of Female Employees: 546 (estimated)
|
Safety Information
| RIDADR | NONH for all modes of transport |
|---|
| WGK Germany | 3 |
|---|
| RTECS | GM7915000 |
|---|
Articles33
More Articles
| An LC-MS/MS method for steroid profiling during adrenal venous sampling for investigation of primary aldosteronism. J. Steroid Biochem. Mol. Biol. 145 , 75-84, (2015) Steroid profiling for diagnosis of endocrine disorders featuring disordered production of steroid hormones is now possible from advances in liquid chromatography with tandem mass spectrometry (LC-MS/M... | |
| The relationship between vitamin D status and adrenal insufficiency in critically ill children. J. Clin. Endocrinol. Metab. 98(5) , E877-81, (2013) Recent studies in critically ill populations have suggested both adrenal insufficiency (AI) and vitamin D deficiency to be associated with worse clinical outcome. There are multiple mechanisms through... | |
| Free and total plasma cortisol measured by immunoassay and mass spectrometry following ACTH₁₋₂₄ stimulation in the assessment of pituitary patients. J. Clin. Endocrinol. Metab. 98(5) , 1883-90, (2013) Measurement of plasma cortisol by immunoassay after ACTH₁₋₂₄ stimulation is used to assess the hypothalamic-pituitary-adrenal (HPA) axis. Liquid chromatography-tandem mass spectrometry (LCMS) has grea... | |
Synonyms
| Cortrosyn |
| y-29-(4-hydroxybenzyl)-26-(hydroxymethyl)-17-(1H-imidazol-4-ylmethyl)-8-(1H-indol-3-ylmethyl)-23-[2-(methylsulfanyl)ethyl]-4,7,10,13,16,19,22,25,28,31-decaoxo-3,6,9,12,15,18,21,24,27,30-decaazatritria |
| L-proline, L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl- |
| MFCD00167476 |
| L-Proline, L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-v alyl-L-lysyl-L-valyl-L-tyrosyl- |
| cosyntropin |
| α1-24-Corticotropin |
| L-Seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-proline |
| EINECS 241-031-1 |
| Adrenocorticotropic Hormone Fragment 1-24 human, rat |
| Tetracosactide |
| L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysy |
| L-Seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysy l-L-valyl-L-tyrosyl-L-proline |
| Porcine ACTH (1-24) |
| Tetracosactide Acetate |
