CAS 1837-57-6|Ethacridine lactate

Introduction：Basic information about CAS 1837-57-6|Ethacridine lactate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Ethacridine lactate BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	Ethacridine lactate
CAS Number	1837-57-6	Molecular Weight	343.377
Density	/	Boiling Point	270 °C(lit.)
Molecular Formula	C₁₈H₂₁N₃O₄	Melting Point	62-67 °C(lit.)
MSDS	/	Flash Point	143 °C

Names

Name	6,9-diamino-2-ethoxyacridine lactate
Synonym	More Synonyms

Ethacridine lactate BiologicalActivity

Description	Ethacridine lactate is a poly(ADP-ribose) glycohydrolase (PARG) inhibitor.
Related Catalog	Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection
Target	PARG[1]
In Vitro	Ethacridine lactate is effective against mostly gram-positive species like Streptococci and Staphylococci and ineffective against gram-negative(P seudomonas aeruginosa)[1]. Ethacridine Lactate is a safe abortifacient with about 80% success and hardly any side effects[2].
In Vivo	The incidence of retained placenta is 16%. The extra-amniotic injection is a technically simple procedure and can be carried out even between 13-15 weeks of pregnancy when intraamniotic injection is difficult. Its bactericidal properties minimize the danger of post-abortal infection. It can be used in certain medical conditions like hypertension, bronchial asthma where hypertonic saline and prostaglandin are contraindi-cated[2]. Ethacridine lactate performs better than other instillation abortion methods and it is a safe and effective method. Ethacridine lactate induces successful abortion in 92.8% of cases which is much higher than that found in the literature (about 82%). Abortion failure occurrs in the other 4 cases because of transverse lie of fetus, cervical dystocia, and uterine inertia[2].
References	[1]. Rotin LE, et al. Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells. Haematologica. 2016 Nov;101(11):e449-e453. [2]. Purandare VN, et al. The place of ethacridine lactate for mid-trimester M.T.P. (Multicentric study). J Postgrad Med. 1977 Apr;23(2):77-83. [3]. Gupta S, et al. Ethacridine lactate -- a safe and effective drug for termination of pregnancy. Indian J Matern Child Health. 1993;4(2):59-61.

Chemical & Physical Properties

Boiling Point	270 °C(lit.)
Melting Point	62-67 °C(lit.)
Molecular Formula	C₁₈H₂₁N₃O₄
Molecular Weight	343.377
Flash Point	143 °C
Exact Mass	343.153198
PSA	131.69000
LogP	3.56530
Vapour Pressure	4.72E-11mmHg at 25°C
InChIKey	IYLLULUTZPKQBW-UHFFFAOYSA-N
SMILES	CC(O)C(=O)O.CCOc1ccc2nc3cc(N)ccc3c(N)c2c1
Water Solubility	soluble

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OD4725000

CAS REGISTRY NUMBER :: 1837-57-6

LAST UPDATED :: 199806

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C15-H15-N3-O.C3-H6-O3

MOLECULAR WEIGHT :: 343.42

WISWESSER LINE NOTATION :: T C666 BNJ EZ IZ LO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Vascular - shock

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 48 gm/kg/30D-C

TOXIC EFFECTS :: Endocrine - other changes Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 420 mg/kg/21D-I

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in spleen weight

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Microorganism - not otherwise specified

DOSE/DURATION :: 250 mg/L

REFERENCE :: PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 56,500,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5763 No. of Facilities: 23 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 23 (estimated)

Safety Information

Hazard Codes	Xi,Xn
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin . R22:Harmful if swallowed. R40:Limited evidence of a carcinogenic effect. R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
Safety Phrases	S26-S24/25-S37/39
WGK Germany	3
RTECS	UT6410000
HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

Ethacridine Lactate

RIVANOL

rivinol

2-Hydroxypropanoic acid - 7-ethoxy-3,9-acridinediamine (1:1)

7-ethoxy-acridine-3,9-diyldiamine,DL lactate

rimaon

MFCD00013149

2-ethoxy-6,9-diaminoacridine lactate

UNII:7T7T2I9823

Propanoic acid, 2-hydroxy-, compd. with 7-ethoxy-3,9-acridinediamine (1:1)

flavitrol

EINECS 217-408-1

ETHODIN

TCMDC-123983

ACRYNOL

metifex

2-Hydroxypropanoic acid - 7-ethoxyacridine-3,9-diamine (1:1)

Vucine

ACRINOL

Ethacridine (lactate)

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