Introduction：Basic information about CAS 31698-14-3|Ancitabine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ancitabine |
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| CAS Number | 31698-14-3 | Molecular Weight | 225.20100 |
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| Density | 2.01 g/cm3 | Boiling Point | 422.2ºCat 760 mmHg |
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| Molecular Formula | C9H11N3O4 | Melting Point | 269-270ºC |
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| MSDS | / | Flash Point | / |
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Names
| Name | ancitabine |
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| Synonym | More Synonyms |
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Ancitabine BiologicalActivity
| Description | Ancitabine is an antileukemia drug[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| References | [1]. Z Rao, et al. Study on the Synthesis of Cytarabine Hydrochloride and its Intermediate Ancitabine Hydrochloride. Fine Chemical Intermediates, 2013 |
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Chemical & Physical Properties
| Density | 2.01 g/cm3 |
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| Boiling Point | 422.2ºCat 760 mmHg |
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| Melting Point | 269-270ºC |
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| Molecular Formula | C9H11N3O4 |
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| Molecular Weight | 225.20100 |
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| Exact Mass | 225.07500 |
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| PSA | 100.59000 |
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| Index of Refraction | 1.5100 (estimate) |
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| InChIKey | BBDAGFIXKZCXAH-CCXZUQQUSA-N |
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| SMILES | N=c1ccn2c(n1)OC1C(O)C(CO)OC12 |
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| Storage condition | −20°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- LV2610000
- CAS REGISTRY NUMBER :
- 31698-14-3
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C9-H11-N3-O4
- MOLECULAR WEIGHT :
- 225.23
- WISWESSER LINE NOTATION :
- T B556 AN CO GO INYTT&J D1Q EQ JUM
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >7 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1700 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory stimulation
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 820 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3400 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory stimulation
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1600 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory stimulation
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4050 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2745 mg/kg/9W-I
- TOXIC EFFECTS :
- Endocrine - changes in adrenal weight Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases
MUTATION DATA - TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Human Leukocyte
- DOSE/DURATION :
- 700 ug/L
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 23,1235,1974
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Safety Information
| WGK Germany | 2 |
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| RTECS | LV2615000 |
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Synonyms
| anhydroarac |
| CYCLOCYTIDINE HCL |
| Cyclocytidine |
| Ancitabine |
| 2,2'-(1,4-CYCLOHEXANEDIYLIDENE)-BISPROPANEDINITRILE |
| 2,2'-ANHYDRO-L-CYTIDINE |
| 2,2'-anhydrocytidine |
| anhydrocytidine |
| cyclocitidine |
| ancytabine |
