CAS 636-54-4|Clopamide
| Common Name | Clopamide | ||
|---|---|---|---|
| CAS Number | 636-54-4 | Molecular Weight | 345.845 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C14H20ClN3O3S | Melting Point | 244-246ºC |
| MSDS | / | Flash Point | / |
| Symbol | GHS08 | Signal Word | Danger |
Names
| Name | Clopamide |
|---|---|
| Synonym | More Synonyms |
Clopamide BiologicalActivity
| Description | Clopamide is an orally active thiazide-like diuretic agent that inhibits the sodium-coupled chloride cotransporter SLC12A3. Clopamide has the potential for hypertension and cardiac failure research[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
| In Vitro | Clopamide is actively secreted by renal tubular cells and the True Tubular Excretion Fraction (TTEF) value is 10%[3]. |
| In Vivo | The venoconstrictor response to bradykinin is attenuated after oral administration of Clopamide (0.5 mg/kg), and by concomitant local infusion of cyclosporine-A (1-10 μg/min) in conscious dogs[4]. |
| References | [1]. J J McNeil, et al. Clopamide: plasma concentrations and diuretic effect in humans. Clin Pharmacol Ther. 1987 Sep;42(3):299-304. [2]. Yoshiteru Noutoshi, et al. Diuretics prime plant immunity in Arabidopsis thaliana. PLoS One. 2012;7(10):e48443. [3]. B Odlind, et al. Renal tubular secretion and effects of chlorothiazide, hydrochlorothiazide and clopamide: a study in the avian kidney. Acta Pharmacol Toxicol (Copenh). 1982 Sep;51(3):187-97. [4]. E Müller-Schweinitzer, et al. Interaction of cyclosporine-A with the renin-angiotensin system in canine veins. Naunyn Schmiedebergs Arch Pharmacol. 1989 Aug;340(2):252-7. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Melting Point | 244-246ºC |
| Molecular Formula | C14H20ClN3O3S |
| Molecular Weight | 345.845 |
| Exact Mass | 345.091400 |
| PSA | 100.88000 |
| LogP | 1.59 |
| Index of Refraction | 1.613 |
| InChIKey | LBXHRAWDUMTPSE-AOOOYVTPSA-N |
| SMILES | CC1CCCC(C)N1NC(=O)c1ccc(Cl)c(S(N)(=O)=O)c1 |
| Storage condition | 2-8°C |
Safety Information
| Symbol | GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H317-H334 |
| Precautionary Statements | P261-P280-P284-P304 + P340-P342 + P311 |
| Hazard Codes | Xn |
| Risk Phrases | R42/43 |
| Safety Phrases | 36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2935009090 |
Customs
| HS Code | 2935009090 |
|---|---|
| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
Articles3
More Articles| Ultra high performance supercritical fluid chromatography coupled with tandem mass spectrometry for screening of doping agents. I: Investigation of mobile phase and MS conditions. Anal. Chim. Acta 853 , 637-46, (2014) The conditions for the analysis of selected doping substances by UHPSFC-MS/MS were optimized to ensure suitable peak shapes and maximized MS responses. A representative mixture of 31 acidic and basic ... | |
| Ultra high performance supercritical fluid chromatography coupled with tandem mass spectrometry for screening of doping agents. II: Analysis of biological samples. Anal. Chim. Acta 853 , 647-59, (2014) The potential and applicability of UHPSFC-MS/MS for anti-doping screening in urine samples were tested for the first time. For this purpose, a group of 110 doping agents with diverse physicochemical p... | |
| Effects of pindolol, or a pindolol/clopamide combination preparation, on plasma lipid levels in essential hypertension. Hunter Hypertension Research Group. Med. J. Aust. 150(11) , 646, 648, 651-2, (1989) In an open study that was conducted in general practice, 22 patients with previously-untreated mild hypertension received an average daily dose of 11.7 mg of pindolol over a 50-week study period. The ... |
Synonyms
| EINECS 211-261-7 |
| Brinaldix |
| DT-327 |
| 4-Chloro-N-[(2R,6S)-2,6-dimethyl-1-piperidinyl]-3-sulfamoylbenzamide |
| Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,6-dimethyl-1-piperidinyl)-, cis- |
| CLOPAMIDUM |
| ChlosudiMepriMyl |
| Adurix |
| MFCD00941495 |
| 4-Chloro-N-(2,6-dimethylpiperidino)-3-sulfamoylbenzamide |
| 3-(aminosulfonyl)-4-chloro-N-(2,6-dimethylpiperidin-1-yl)benzamide |
| Aquex |
| 4-Chloro-N-(2,6-dimethylpiperidin-1-yl)-3-sulfamoylbenzamide |
| Benzamide, 3-(aminosulfonyl)-4-chloro-N-[(2R,6S)-2,6-dimethyl-1-piperidinyl]- |
| Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,6-dimethyl-1-piperidinyl)- |
| 4-Chloro-N-(2,6-dimethyl-1-piperidinyl)-3-sulfamoylbenzamide |
