Introduction：Basic information about CAS 136259-20-6|P32/98, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | P32/98 |
|---|
| CAS Number | 136259-20-6 | Molecular Weight | 520.70600 |
|---|
| Density | / | Boiling Point | / |
|---|
| Molecular Formula | C22H40N4O6S2 | Melting Point | / |
|---|
| MSDS | / | Flash Point | / |
|---|
Names
| Name | 2-amino-3-methyl-1-(1,3-thiazolidin-3-yl)pentan-1-one,but-2-enedioic acid |
|---|
| Synonym | More Synonyms |
|---|
P32/98 BiologicalActivity
| Description | P32/98 is a potent inhibitor of dipeptidyl peptidase IV. P32/98 improves glucose tolerance, insulin sensitivity and β-cell responsiveness in preclinical studies using the fatty Zucker rat, an animal model for IGT (impaired glucose tolerance)[1]. |
|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Dipeptidyl PeptidaseResearch Areas >>Metabolic Disease |
|---|
| Target | DPP4[1] |
|---|
| In Vivo | P32/98 (25 mg/kg; i.g.; once daily) long-time treatment significantly improves the glucose tolerance in Zucker diabetic fatty rats[2]. Animal Model: Zucker diabetic fatty rat[2] Dosage: 25 mg/kg Administration: i.g., once daily Result: Significantly improved the glucose tolerance in Zucker diabetic fatty rats. |
|---|
| References | [1]. Augstein P, et al. Efficacy of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide (P32/98) in fatty Zucker rats with incipient and manifest impaired glucose tolerance. Diabetes Obes Metab. 2008;10(10):850-861. [2]. Wargent E, et al. Improvement of glucose tolerance in Zucker diabetic fatty rats by long-term treatment with the dipeptidyl peptidase inhibitor P32/98: comparison with and combination with rosiglitazone. Diabetes Obes Metab. 2005;7(2):170-181. |
|---|
Chemical & Physical Properties
| Molecular Formula | C22H40N4O6S2 |
|---|
| Molecular Weight | 520.70600 |
|---|
| Exact Mass | 520.23900 |
|---|
| PSA | 217.86000 |
|---|
| LogP | 2.77360 |
|---|
Synonyms
| P32/98 |
| L-threo-isoleucyl thiazolidine |
| isoleucine thiazolide |
| L-threo-isoleucyl rhiazolidine |
