CAS 314266-76-7|OM99-2 trifluoroacetate salt
| Common Name | OM99-2 trifluoroacetate salt | ||
|---|---|---|---|
| CAS Number | 314266-76-7 | Molecular Weight | 892.99200 |
| Density | 1.311g/cm3 | Boiling Point | 1322.4ºC at 760mmHg |
| Molecular Formula | C41H64N8O14 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 753.6ºC |
Names
| Name | Glu-Val-Asn-[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyloctanoyl]-Ala-Glu-Phe |
|---|---|
| Synonym | More Synonyms |
OM99-2 trifluoroacetate salt BiologicalActivity
| Description | OM99-2, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a Ki value of 9.58 nM[1]. OM99-2 is significantly advanced the development of BACE1 inhibitor[2], has the potential for the research of the Alzheimer's disease[3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Beta-secretaseResearch Areas >>Neurological Disease |
| Target | Ki: 9.58 nM (memapsin 2) |
| In Vitro | Memapsin 2 (BACE) is an aspartyl protease known as beta-secretase that acts on the production of the beta-amyloid peptide in the human brain[4]. |
| References | [1]. Ghosh AK, et al. Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase). J Am Chem Soc. 2000;122(14):3522-3523. [2]. Zhao J, et al. Targeting Amyloidogenic Processing of APP in Alzheimer's Disease. Front Mol Neurosci. 2020;13:137. Published 2020 Aug 4. [3]. Dash C, et al. Aspartic peptidase inhibitors: implications in drug development. Crit Rev Biochem Mol Biol. 2003;38(2):89-119. [4]. Park H, et al. Determination of the active site protonation state of beta-secretase from molecular dynamics simulation and docking experiment: implications for structure-based inhibitor design. J Am Chem Soc. 2003;125(52):16416-16422. |
Chemical & Physical Properties
| Density | 1.311g/cm3 |
|---|---|
| Boiling Point | 1322.4ºC at 760mmHg |
| Molecular Formula | C41H64N8O14 |
| Molecular Weight | 892.99200 |
| Flash Point | 753.6ºC |
| Exact Mass | 892.45400 |
| PSA | 375.84000 |
| LogP | 2.00990 |
| Index of Refraction | 1.562 |
| InChIKey | NIOCOJFPGCXNKL-VZXRQOAXSA-N |
| SMILES | CC(C)CC(NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CCC(=O)O)C(C)C)C(O)CC(C)C(=O)NC(C)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1ccccc1)C(=O)O |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
Articles4
More Articles| Inhibitors of Alzheimer's BACE-1 with 3,5-bis-N-(aryl/heteroaryl) carbamoyl-4-aryl-1,4-dihydropyridine structure. Arch. Pharm. Res. 38(4) , 456-69, (2015) β-site amyloid precursor protein cleaving enzyme (BACE-1) is a validated target for Alzheimer therapy due to its distinctive role in pathogenesis of AD. In the present contribution, a series of new 3,... | |
| Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor. Science 290 , 150, (2000) Memapsin 2 (beta-secretase) is a membrane-associated aspartic protease involved in the production of beta-amyloid peptide in Alzheimer's disease and is a major target for drug design. We determined th... | |
| Chlamydia trachomatis prevalence and chlamydial/HPV co-infection among HPV-unvaccinated young Italian females with normal cytology. Hum. Vaccin. Immunother. 11(1) , 270-6, (2015) Infections caused by Chlamydia trachomatis (Ct) and human papillomavirus (HPV) are the two main sexually transmitted infections; however, epidemiological data on Ct prevalence and Ct/HPV co-infection ... |
Synonyms
| om99-2 |
| MFCD03787969 |
| H-Glu-Val-Asn-[(2R,4S,5S)-5-amino-4-hydroxy-2 |
