CAS 16662-47-8|Gallopamil
| Common Name | Gallopamil | ||
|---|---|---|---|
| CAS Number | 16662-47-8 | Molecular Weight | 521.08900 |
| Density | 1.068g/cm3 | Boiling Point | 605.9ºC at 760mmHg |
| Molecular Formula | C28H40N2O5 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 320.2ºC |
Names
| Name | 5-((3,4-Dimethoxyphenethyl)(methyl)amino)-2-isopropyl-2-(3,4,5-trimethoxyphenyl)pentanenitrile |
|---|---|
| Synonym | More Synonyms |
Gallopamil BiologicalActivity
| Description | Gallopamil (Methoxyverapamil), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist. Gallopamil acts on the vascular system and the heart and nodal structure[1]. Gallopamil inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM[2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelResearch Areas >>Neurological Disease |
| Target | Ca2+ |
| References | [1]. Brogden RN, et al. Gallopamil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in ischaemic heart disease. Drugs. 1994 Jan;47(1):93-115. [2]. Sewing KF, et al. Calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells. Pharmacology. 1983;27(1):9-14. |
Chemical & Physical Properties
| Density | 1.068g/cm3 |
|---|---|
| Boiling Point | 605.9ºC at 760mmHg |
| Molecular Formula | C28H40N2O5 |
| Molecular Weight | 521.08900 |
| Flash Point | 320.2ºC |
| Exact Mass | 520.27000 |
| PSA | 73.18000 |
| LogP | 5.66408 |
| Vapour Pressure | 1.25E-14mmHg at 25°C |
| Index of Refraction | 1.523 |
| InChIKey | XQLWNAFCTODIRK-UHFFFAOYSA-N |
| SMILES | COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC |
| Storage condition | -20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles25
More Articles| Force response to stretches in activated frog muscle fibres at low tension. Adv. Exp. Med. Biol. 538 , 429-38; discussion 438-9, (2003) | |
| Ca2+ pathway involved in the refilling of store sites in rat adrenal medullary cells. Am. J. Physiol. Cell Physiol. 296(4) , C889-99, (2009) It has been suggested that store-operated Ca(2+) entry (SOC) facilitates catecholamine secretion and synthesis in bovine adrenal medullary (AM) cells. However, there has been no experimental result cl... | |
| Effects of phenylalkylamines and benzothiazepines on Ca(v)1.3-mediated Ca2+ currents in neonatal mouse inner hair cells. Eur. J. Pharmacol. 573(1-3) , 39-48, (2007) Calcium currents (I(Ca)) in inner hair cells (IHCs) are carried by the Ca(v)1.3 subtype of L-type calcium channels. They play an important role in synaptic transmission of sound-evoked mechanical stim... |
Synonyms
| MFCD00058000 |
| 5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-yl-2-(3,4,5-trimethoxyphenyl)pentanenitrile |
