Introduction：Basic information about CAS 132173-07-0|SR-31747, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | SR-31747 |
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| CAS Number | 132173-07-0 | Molecular Weight | 396.43700 |
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| Density | / | Boiling Point | 479.9ºC at 760 mmHg |
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| Molecular Formula | C23H35Cl2N | Melting Point | / |
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| MSDS | / | Flash Point | 244.1ºC |
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Names
| Name | N-[(Z)-3-(3-chloro-4-cyclohexylphenyl)prop-2-enyl]-N-ethylcyclohexanamine,hydrochloride |
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| Synonym | More Synonyms |
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SR-31747 BiologicalActivity
| Description | SR-31747 is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase[1][2]. |
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| Related Catalog | Research Areas >>Inflammation/ImmunologySignaling Pathways >>GPCR/G Protein >>Sigma Receptor |
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| Target | Sigma ligand[1] |
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| In Vitro | SR-31747 blocks the proliferation of lymphocytes at a concentration of 10 nM. SR-31747 is capable of inhibiting T-cell proliferation when added as late as 24 h after activation. SR-31747 arrests proliferation in yeast cells in a dose-dependent manner[2]. |
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| In Vivo | In vivo, SR-31747 dramatically blocks lipopolysaccharide-induced production of IL-1, IL-6 and TNF-α in a dose-dependent manner (ED50, 2 mg/kg). SR-31747 probably abrogated monokine production through an indirect mechanism that involves endogenous corticosteroids. This conclusion was supported by in vivo experiments that shows that: 1) ablation of corticosteroids by use of Mifepristone or adrenalectomy suppress the effect of SR-31747; 2) administration of SR-31747 induces an enhancement of the corticosterone level. SR-31747 improves the survival of animals with endotoxinic shock as a result of monokine inhibition[1]. |
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| References | [1]. Derocq JM, et al. In vivo inhibition of endotoxin-induced pro-inflammatory cytokines production by the sigma ligand SR 31747. J Pharmacol Exp Ther. 1995 Jan;272(1):224-30. [2]. Silve S, et al. The immunosuppressant SR 31747 blocks cell proliferation by inhibiting a steroid isomerase in Saccharomyces cerevisiae. Mol Cell Biol. 1996 Jun;16(6):2719-27. |
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Chemical & Physical Properties
| Boiling Point | 479.9ºC at 760 mmHg |
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| Molecular Formula | C23H35Cl2N |
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| Molecular Weight | 396.43700 |
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| Flash Point | 244.1ºC |
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| Exact Mass | 395.21500 |
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| PSA | 3.24000 |
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| LogP | 7.85750 |
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| Vapour Pressure | 2.26E-09mmHg at 25°C |
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| InChIKey | HKHPCMBPASXYGP-KVVVOXFISA-N |
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| SMILES | CCN(CC=Cc1ccc(C2CCCCC2)c(Cl)c1)C1CCCCC1.Cl |
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| Storage condition | 2-8°C |
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Safety Information
Customs
| HS Code | 2921499090 |
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| Summary | 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| (Z)-N-(3-(3-Chloro-4-cyclohexylphenyl)allyl)-N-ethylcyclohexanamine hydrochloride |
| (Z)-N-(3-(3-Chloro-4-cyclohexylphenyl)-2-propenyl)-N-ethylcyclohexanamine hydrochloride |
