Introduction：Basic information about CAS 162408-66-4|GR 103691, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | GR 103691 |
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| CAS Number | 162408-66-4 | Molecular Weight | 485.617 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 688.7±55.0 °C at 760 mmHg |
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| Molecular Formula | C30H35N3O3 | Melting Point | / |
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| MSDS | USA | Flash Point | 370.3±31.5 °C |
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Names
| Name | 4-(4-acetylphenyl)-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide |
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| Synonym | More Synonyms |
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GR 103691 BiologicalActivity
| Description | GR 103691 is a potent, selective dopamine D3 receptor antagonist with a Ki value of 0.4 nM. GR 103691 shows more than 100-fold selectivity for human dopamine human (h)D3 over hD4 and hD1 sites[1]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease |
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| Target | Ki: 0.4 nM (Human dopamine D3 receptor)[1] |
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| In Vitro | GR 103691 shows marked affinity for serotonin1A (5-HT1A) receptors (Ki of 5.8 nM) and α-1 adrenoceptors (Ki of 12.6 nM)[1]. |
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| References | [1]. Audinot V, et al. A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194. J Pharmacol Exp Ther. 1998 Oct;287(1):187-97. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 688.7±55.0 °C at 760 mmHg |
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| Molecular Formula | C30H35N3O3 |
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| Molecular Weight | 485.617 |
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| Flash Point | 370.3±31.5 °C |
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| Exact Mass | 485.267853 |
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| PSA | 61.88000 |
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| LogP | 4.47 |
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| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
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| Index of Refraction | 1.582 |
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| InChIKey | JARNORYOPMINDY-UHFFFAOYSA-N |
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| SMILES | COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(C(C)=O)cc3)cc2)CC1 |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Safety Phrases | S22-S24/25 |
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| RIDADR | NONH for all modes of transport |
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Synonyms
| 4'-Acetyl-N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}biphenyl-4-carboxamide |
| 4'-Acetyl-N-{4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl}-4-biphenylcarboxamide |
| Tocris-1109 |
| [1,1'-Biphenyl]-4-carboxamide, 4'-acetyl-N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]- |
| MFCD00936840 |
