CAS 317-52-2|Hexafluronium Bromide

Introduction:Basic information about CAS 317-52-2|Hexafluronium Bromide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameHexafluronium Bromide
CAS Number317-52-2Molecular Weight662.54000
Density/Boiling Point/
Molecular FormulaC36H42Br2N2Melting Point/
MSDS/Flash Point/

Names

Name9H-fluoren-9-yl-[6-[9H-fluoren-9-yl(dimethyl)azaniumyl]hexyl]-dimethylazanium,dibromide
SynonymMore Synonyms

Hexafluronium Bromide BiologicalActivity

DescriptionHexafluorenium dibromide (Mylaxen) is a potent cholinesterase (ChE) inhibitor with pI50 value of 6.96 and Ki value of 2.4 nM for human plasma cholinesterase (ChE)[1].
Related CatalogResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>AChE

Chemical & Physical Properties

Molecular FormulaC36H42Br2N2
Molecular Weight662.54000
Exact Mass660.17100
LogP2.24760

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BQ8225000
CHEMICAL NAME :
Ammonium, hexamethylenebis(fluoren-9-yldimethyl-, dibromide
CAS REGISTRY NUMBER :
317-52-2
LAST UPDATED :
199012
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C36-H42-N2.2Br
MOLECULAR WEIGHT :
662.62
WISWESSER LINE NOTATION :
L B656 HHJ HK1&1&6K1&1&- HL B656 HHJ &E 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human
DOSE/DURATION :
400 ug/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
REFERENCE :
85IVAW "Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents," National Research Council, 3 vols., Washington, DC, National Academy Press, 1982-85 Volume(issue)/page/year: 1,E1,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 85,603,1954
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
240 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 85,603,1954
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1760 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 2,233,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
80 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 22,200,1959

Safety Information

HS Code2923900090

Customs

HS Code2923900090
Summary2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Synonyms

N,N'-di-fluoren-9-yl-N,N,N',N'-tetramethyl-N,N'-hexanediyl-di-ammonium,dibromide
Esafluronio bromuro
Milaxen
Hexafluorenium dibromide
hexafluorenium bromide
Hexafluroniumbromid
hexafluorenium
Hexafluronii bromidum
N,N'-Di-fluoren-9-yl-N,N,N',N'-tetramethyl-N,N'-hexandiyl-di-ammonium,Dibromid
Hexafluronium bromide
Mylaxen
N,N'-di-9H-fluoren-9-yl-N,N,N',N'-tetramethyl-1,6-hexanediaminium
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