Introduction：Basic information about CAS 134865-70-6|8-M-PDOT, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 8-M-PDOT |
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| CAS Number | 134865-70-6 | Molecular Weight | 233.30600 |
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| Density | 1.09g/cm3 | Boiling Point | 447.8ºC at 760 mmHg |
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| Molecular Formula | C14H19NO2 | Melting Point | / |
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| MSDS | / | Flash Point | 224.6ºC |
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Names
| Name | N-[(2R)-8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl]propanamide |
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| Synonym | More Synonyms |
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8-M-PDOT BiologicalActivity
| Description | 8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity[1][2]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Melatonin ReceptorSignaling Pathways >>GPCR/G Protein >>Melatonin ReceptorResearch Areas >>Neurological Disease |
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| Target | pKi: 8.23 (Melatonin MT2 receptor) and 8.95 (Melatonin MT1 receptor)[2] |
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| In Vivo | 8-M-PDOT (10 µg/µL; administrated into the dorsal striatum by bilateral cannulas; for 30 minutes; male Wistar rats) treatment shows anxiolytic-like effect[2]. Animal Model: Male Wistar rats (280-320 g) with Rotenone[2] Dosage: 10 µg/µL Administration: Administrated into the dorsal striatum by bilateral cannulas; for 30 minutes Result: Increased percentage of time spent in the open arms and in the number of open arms entries. |
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| References | [1]. Browning C, et al. Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors. Br J Pharmacol. 2000 Mar;129(5):877-86. [2]. Noseda AC, et al. REM sleep deprivation promotes a dopaminergic influence in the striatal MT2 anxiolytic-like effects. Sleep Sci. 2016 Jan-Mar;9(1):47-54. |
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Chemical & Physical Properties
| Density | 1.09g/cm3 |
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| Boiling Point | 447.8ºC at 760 mmHg |
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| Molecular Formula | C14H19NO2 |
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| Molecular Weight | 233.30600 |
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| Flash Point | 224.6ºC |
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| Exact Mass | 233.14200 |
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| PSA | 38.33000 |
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| LogP | 2.46960 |
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| Vapour Pressure | 3.27E-08mmHg at 25°C |
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| Index of Refraction | 1.542 |
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| InChIKey | RVIGBTUDFAGRTQ-UHFFFAOYSA-N |
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| SMILES | CCC(=O)NC1CCc2cccc(OC)c2C1 |
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Synonyms
| 8-methoxy-2-propionamidotetralin |
| Tocris-1035 |
| 8-M-PDOT |
