Introduction：Basic information about CAS 161748-29-4|GLP-1 (9-36) amide TFA, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | GLP-1 (9-36) amide TFA |
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| CAS Number | 161748-29-4 | Molecular Weight | 3089.41000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C140H214N36O43 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | GLP-1 (9-36) amide |
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| Synonym | More Synonyms |
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GLP-1 (9-36) amide TFA BiologicalActivity
| Description | GLP-1(9-36)amide is a major metabolite of glucagon-like peptide-1-(7-36) amide formed by the enzyme dipeptidyl peptidase-4 (DPP-4). GLP-1(9-36)amide acts as an antagonist to the human pancreatic GLP-1 receptor[1][2]. |
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| Related Catalog | Research Areas >>Metabolic DiseaseSignaling Pathways >>GPCR/G Protein >>Glucagon Receptor |
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| In Vitro | GLP-1(9-36)amide potently inhibits hepatic glucose production (HGP) and is a weak insulinotropic agent[2]. |
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| References | [1]. Knudsen LB, et al. Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor. Eur J Pharmacol. 1996;318(2-3):429-435. [2]. Elahi D, et al. GLP-1 (9-36) amide, cleavage product of GLP-1 (7-36) amide, is a glucoregulatory peptide. Obesity (Silver Spring). 2008;16(7):1501-1509. |
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Chemical & Physical Properties
| Molecular Formula | C140H214N36O43 |
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| Molecular Weight | 3089.41000 |
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| Exact Mass | 3087.57000 |
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| PSA | 1298.21000 |
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| LogP | 2.29160 |
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| InChIKey | WPNGPBPCQMDAAD-WRFZDFFOSA-N |
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| SMILES | CCC(C)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(=O)O)NC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCC(N)=O)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)CNC(=O)C(N)CCC(=O)O)C(C)O)C(C)O)C(C)C)C(=O)NC(C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(C(=O)NC(CCCCN)C(=O)NCC(=O)NC(CCCNC(=N)N)C(N)=O)C(C)C |
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Synonyms
| h-glu-gly-thr-phe-thr-ser-asp-val-ser-ser-tyr-leu-glu-gly-gln-ala-ala-lys-glu-phe-ile-ala-trp-leu-val-lys-gly-arg-nh2 |
