Introduction：Basic information about CAS 3116-76-5|Dicloxacillin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dicloxacillin |
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| CAS Number | 3116-76-5 | Molecular Weight | 470.326 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | 692.4±55.0 °C at 760 mmHg |
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| Molecular Formula | C19H17Cl2N3O5S | Melting Point | / |
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| MSDS | / | Flash Point | 372.5±31.5 °C |
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Names
| Name | dicloxacillin |
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| Synonym | More Synonyms |
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Dicloxacillin BiologicalActivity
| Description | Dicloxacillin is a β-lactam antibiotic of the penicillin family. Dicloxacillin against Gram-positive bacteria. Dicloxacillin is active against β-lactamase-producing organisms such as Staphylococcus aureus[1]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| In Vitro | Dicloxacillin exhibits EC50 values of 0.06 and 0.50 mg/L in ATCC 25923 and E19977, respectively. Dicloxacillin exhibits MIC values of 0.125 and 0.5 mg/L in ATCC 25923 and E19977 with pH 7.4, respectively[2]. |
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| In Vivo | Dicloxacillin exhibits therapeutic activity in murine peritonitis-sepsis model and all the mice are survivied[3]. Animal Model: Female outbred Swiss Webster mice (Murine peritonitis-sepsis model)[3]. Dosage: 125 mg/kg. Administration: IV injection, single doses. Result: All the mice survived. |
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| References | [1]. Miranda-Novales G, et al. In vitro activity effects of combinations of cephalothin, dicloxacillin, imipenem, vancomycin and amikacin against methicillin-resistant Staphylococcus spp. strains. Ann Clin Microbiol Antimicrob. 2006 Oct 12;5:25. [2]. Anne Sandberg, et al. Intra- and extracellular activities of dicloxacillin against Staphylococcus aureus in vivo and in vitro. Antimicrob Agents Chemother. 2010 Jun;54(6):2391-400. [3]. John Chu, et al. Discovery of MRSA active antibiotics using primary sequence from the human microbiome. Nat Chem Biol. 2016 Dec;12(12):1004-1006. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 692.4±55.0 °C at 760 mmHg |
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| Molecular Formula | C19H17Cl2N3O5S |
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| Molecular Weight | 470.326 |
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| Flash Point | 372.5±31.5 °C |
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| Exact Mass | 469.026581 |
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| PSA | 138.04000 |
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| LogP | 3.02 |
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| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
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| Index of Refraction | 1.691 |
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| InChIKey | YFAGHNZHGGCZAX-JKIFEVAISA-N |
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| SMILES | Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)NC1C(=O)N2C1SC(C)(C)C2C(=O)O |
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| Water Solubility | 3.63 mg/L |
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Synonyms
| Dicloxacillin |
| Pathocil |
| (2S,5R,6R)-6-({[3-(2,6-dichlorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| (2S,5R,6R)-6-({[3-(2,6-Dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| dicluxacillin |
| (2S,5R,6R)-6-[[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| EINECS 221-488-3 |
| Dicloxacycline |
| Dynapen |
| 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)- |
| Dicloxacilina |
| Maclicine |
| MFCD00210902 |
| Dicloxacilin |
| Dycill |
| (2S-(2a,5a,6b))-6-(((3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid |
| Dicloxacillinum |
| (2S,5R,6R)-6-(((3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid |
