CAS 39445-21-1|Elastase from porcine pancreas
| Common Name | Elastase from porcine pancreas | ||
|---|---|---|---|
| CAS Number | 39445-21-1 | Molecular Weight | 474.93574 |
| Density | / | Boiling Point | / |
| Molecular Formula | C20H31N4O7Cl | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07, GHS08 | Signal Word | Danger, Warning |
Names
| Name | human neutrophil |
|---|---|
| Synonym | More Synonyms |
Elastase from porcine pancreas BiologicalActivity
| Description | Elastase from porcine pancreas is a single polypeptide chain of 240 amino acid residues. Elastase from porcine pancreas is a serine protease that can hydrolyze proteins and polypeptide. Elastase from porcine pancreas can induce emphysema in hamsters[1][2][3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
| In Vivo | Elastase from porcine pancreas induces emphysema in hamsters[3]. |
| References | [1]. Shotton DM, et, al. Amino-acid sequence of porcine pancreatic elastase and its homologies with other serine proteinases. Nature. 1970 Feb 28;225(5235):802-6. [2]. Teshima T, et, al. A new class of heterocyclic serine protease inhibitors. Inhibition of human leukocyte elastase, porcine pancreatic elastase, cathepsin G, and bovine chymotrypsin A alpha with substituted benzoxazinones, quinazolines, and anthranilates. J Biol Chem. 1982 May 10;257(9):5085-91. [3]. Stone PJ, et, al. Induction and exacerbation of emphysema in hamsters with human neutrophil elastase inactivated reversibly by a peptide boronic acid. Am Rev Respir Dis. 1990 Jan;141(1):47-52. |
Chemical & Physical Properties
| Molecular Formula | C20H31N4O7Cl |
|---|---|
| Molecular Weight | 474.93574 |
| Storage condition | -20°C |
Safety Information
| Symbol | GHS07, GHS08 |
|---|---|
| Signal Word | Danger, Warning |
| Hazard Statements | H315-H319-H334-H335 |
| Precautionary Statements | P261-P280-P284-P304 + P340 + P312-P305 + P351 + P338-P337 + P313-P342 + P311 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | R42;R36/37/38 |
| Safety Phrases | S22;S24;S26;S36/S37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Preparation
Articles96
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| Can we predict postoperative pancreatic leakage after pancreaticoduodenectomy using preoperative fecal elastase-1 level? J. Clin. Lab Anal. 27(5) , 379-83, (2013) The measurement of fecal elastas-1 in stools is a sensitive and relatively inexpensive noninvasive test. The aim of this study was to study fecal elastase levels in patients who develop pancreatic lea... | |
| Collagenase mRNA Overexpression and Decreased Extracellular Matrix Components Are Early Events in the Pathogenesis of Emphysema. PLoS ONE 10 , e0129590, (2015) To describe the progression of parenchymal remodeling and metalloproteinases gene expression in earlier stages of emphysema, mice received porcine pancreatic elastase (PPE) instillation and Control gr... |
Synonyms
| MFCD00130998 |
| EINECS 254-453-6 |
