Introduction：Basic information about CAS 1353011-95-6|Chloroacetamido-PEG4-NHS ester, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Chloroacetamido-PEG4-NHS ester |
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| CAS Number | 1353011-95-6 | Molecular Weight | 438.857 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C17H27ClN2O9 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Chloroacetamido-PEG4-NHS ester |
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| Synonym | More Synonyms |
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Chloroacetamido-PEG4-NHS ester BiologicalActivity
| Description | Chloroacetamido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | PEGs Alkyl/ether |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Molecular Formula | C17H27ClN2O9 |
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| Molecular Weight | 438.857 |
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| Exact Mass | 438.140503 |
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| LogP | -3.45 |
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| Index of Refraction | 1.513 |
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| InChIKey | BPWFCYSNJLMFRO-UHFFFAOYSA-N |
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| SMILES | O=C(CCl)NCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O |
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Synonyms
| 2-Chloro-N-{15-[(2,5-dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl}acetamide |
| Acetamide, 2-chloro-N-[15-[(2,5-dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]- |
