Introduction：Basic information about CAS 1349904-82-0|Taccalonolide AJ, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Taccalonolide AJ |
|---|
| CAS Number | 1349904-82-0 | Molecular Weight | 676.70500 |
|---|
| Density | / | Boiling Point | / |
|---|
| Molecular Formula | C34H44O14 | Melting Point | / |
|---|
| MSDS | / | Flash Point | / |
|---|
Names
Taccalonolide AJ BiologicalActivity
| Description | Taccalonolide AJ is a semi-synthesis compound with cellular microtubule stabilizing activity. Taccalonolide AJ exhibits high potency antiproliferative activity against cancer cells, with an IC50 of 4.2 nM for HeLa cells[1]. |
|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Microtubule/TubulinSignaling Pathways >>Cytoskeleton >>Microtubule/Tubulin |
|---|
| Target | microtubule[1] |
|---|
| References | [1]. Li J, et al. Potent taccalonolides, AF and AJ, inform significant structure-activity relationships and tubulin as the binding site of these microtubule stabilizers. J Am Chem Soc. 2011 Nov 30;133(47):19064-7. |
|---|
Chemical & Physical Properties
| Molecular Formula | C34H44O14 |
|---|
| Molecular Weight | 676.70500 |
|---|
| Exact Mass | 676.27300 |
|---|
| PSA | 208.02000 |
|---|
| LogP | 0.05300 |
|---|
| InChIKey | BWKYBGRKQMTOQL-MPOFNYKTSA-N |
|---|
| SMILES | CC(=O)OC1C(OC(C)=O)C2(C)C(C(O)C3C2C(C)C2OC24OC(=O)C(C)(O)C34C)C2C(O)C(=O)C3CC4OC4C(OC(C)=O)C3(C)C12 |
|---|
| Storage condition | 2-8℃ |
|---|
