CAS 1612888-66-0|Alofanib

Introduction：Basic information about CAS 1612888-66-0|Alofanib, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Alofanib BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Alofanib
CAS Number	1612888-66-0	Molecular Weight	413.40
Density	1.5±0.1 g/cm3	Boiling Point	659.6±65.0 °C at 760 mmHg
Molecular Formula	C₁₉H₁₅N₃O₆S	Melting Point	/
MSDS	/	Flash Point	352.7±34.3 °C

Names

Name	Alofanib
Synonym	More Synonyms

Alofanib BiologicalActivity

Description	Alofanib (RPT835) is a potent and selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2). Anticancer activities[1]. Antiangiogenic Activity[2].
Related Catalog	Research Areas >>CancerResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>Protein Tyrosine Kinase/RTK >>FGFR
Target	FGFR2
In Vitro	Alofanib inhibits phosphorylation of FRS2α with IC50s of 7 and 9 nM in cancer cells expressing different FGFR2 isoforms[1]. Alofanib (10-1000 nM) inhibits FGF-mediated proliferation in a panel of four cell lines representing several tumour types (triple-negative breast cancer, melanoma, and ovarian cancer with GI50s of 16-370 nM[1].
In Vivo	In a FGFR-driven human tumour xenograft model, oral administration of alofanib (30 mg/kg) is well tolerated and resulted in potent antitumour activity[1]. Treatment with alofanib ablated experimental FGF-induced angiogenesis in vivo[1].
References	[1]. Tsimafeyeu I, et al. Targeting FGFR2 with alofanib (RPT835) shows potent activity in tumour models. Eur J Cancer. 2016 Jul;61:20-8. [2]. Khochenkov DA, et al. Antiangiogenic Activity of Alofanib, an Allosteric Inhibitor of Fibroblast Growth Factor Receptor 2. Bull Exp Biol Med. 2015 Nov;160(1):84-7.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	659.6±65.0 °C at 760 mmHg
Molecular Formula	C₁₉H₁₅N₃O₆S
Molecular Weight	413.40
Flash Point	352.7±34.3 °C
Exact Mass	413.068146
LogP	4.00
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.667
InChIKey	QUQGQIASFYWKAB-UHFFFAOYSA-N
SMILES	Cc1cc([N+](=O)[O-])c(NS(=O)(=O)c2cccc(C(=O)O)c2)cc1-c1cccnc1
Storage condition	-20℃

Synonyms

3-{[4-Methyl-2-nitro-5-(3-pyridinyl)phenyl]sulfamoyl}benzoic acid

Benzoic acid, 3-[[[4-methyl-2-nitro-5-(3-pyridinyl)phenyl]amino]sulfonyl]-

Alofanib (RPT835)

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