Introduction：Basic information about CAS 1619994-68-1|GSK 2801, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | GSK 2801 |
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| CAS Number | 1619994-68-1 | Molecular Weight | 371.450 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C20H21NO4S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 1-[1-[2-(Methylsulfonyl)phenyl]-7-propoxy-3-indolizinyl]ethanone |
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| Synonym | More Synonyms |
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GSK 2801 BiologicalActivity
| Description | GSK2801 is a potent, selective and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd=136 nM) and BAZ2B(Kd=257 nM) bromodomains.IC50 value: 136 nM/257 nM(Kd, BAZ2A/BAZ2B) [1]Target: BAZ2A/2B inhibitorGSK2801 binds to BAZ2 bromodomains with dissociation constants (KD) of 136 and 257 nM for BAZ2B and BAZ2A, respectively. Crystal structures demonstrated a canonical acetyl-lysine competitive binding mode. Cellular activity was demonstrated using fluorescent recovery after photobleaching (FRAP) monitoring displacement of GFP-BAZ2A from acetylated chromatin. A pharmacokinetic study in mice showed that GSK2801 had reasonable in vivo exposure after oral dosing, with modest clearance and reasonable plasma stability. Thus, GSK2801 represents a versatile tool compound for cellular and in vivo studies to understand the role of BAZ2 bromodomains in chromatin biology. |
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| Related Catalog | Signaling Pathways >>Epigenetics >>Epigenetic Reader DomainResearch Areas >>Cancer |
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| References | [1]. Chen P, et al. Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B. J Med Chem. 2015 Apr 6. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Molecular Formula | C20H21NO4S |
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| Molecular Weight | 371.450 |
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| Exact Mass | 371.119141 |
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| LogP | 2.95 |
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| Appearance of Characters | light yellow solid |
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| Index of Refraction | 1.596 |
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| InChIKey | KHWCPNJRJCNVRI-UHFFFAOYSA-N |
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| SMILES | CCCOc1ccn2c(C(C)=O)cc(-c3ccccc3S(C)(=O)=O)c2c1 |
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| Storage condition | -20℃ |
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Synonyms
| 1-{1-[2-(Methylsulfonyl)phenyl]-7-propoxy-3-indolizinyl}ethanone |
| Ethanone, 1-[1-[2-(methylsulfonyl)phenyl]-7-propoxy-3-indolizinyl]- |
| GSK 2801 |
| GSK2801 |
