CAS 1624602-30-7|VR23

Introduction：Basic information about CAS 1624602-30-7|VR23, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. VR23 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	VR23
CAS Number	1624602-30-7	Molecular Weight	477.878
Density	1.6±0.1 g/cm3	Boiling Point	699.3±65.0 °C at 760 mmHg
Molecular Formula	C₁₉H₁₆ClN₅O₆S	Melting Point	/
MSDS	/	Flash Point	376.7±34.3 °C

Names

Name	7-Chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]quinoline
Synonym	More Synonyms

VR23 BiologicalActivity

Description	VR23 is a small molecule that potently inhibited the activities of trypsin-like proteasomes (IC50 = 1 nM), chymotrypsin-like proteasomes (IC50 = 50-100 nM), and caspase-like proteasomes (IC50 = 3 μM).IC50 value: 1 nM (trypsin-like proteasome), 50-100 nM(chymotrypsin-like proteasome), 3 μM (caspase-like proteasome)Target: proteasomein vitro: VR23 is a novel proteasome inhibitor targeting β2 of the 20S proteasome subunit. VR23 produces a synergistic effect in killing multiple myeloma cells, including those that were resistant to bortezomib. VR23 as a structurally novel proteasome inhibitor with desirable properties as an anticancer agent.in vivo: VR23 shows effective antitumor and antiangiogenic activities in mice.
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>ProteasomeResearch Areas >>Metabolic Disease
References	[1]. Pundir S, et al. VR23: A Quinoline-Sulfonyl Hybrid Proteasome Inhibitor That Selectively Kills Cancer via Cyclin E-Mediated Centrosome Amplification. Cancer Res. 2015 Oct 1;75(19):4164-4175. [2]. Lee Hoyun, et al. Preparation of quinoline sulfonyl derivatives for the treatment of cancer. From PCT Int. Appl. (2014), WO 2014134705 A1 20140912.

Description

VR23 is a small molecule that potently inhibited the activities of trypsin-like proteasomes (IC50 = 1 nM), chymotrypsin-like proteasomes (IC50 = 50-100 nM), and caspase-like proteasomes (IC50 = 3 μM).IC50 value: 1 nM (trypsin-like proteasome), 50-100 nM(chymotrypsin-like proteasome), 3 μM (caspase-like proteasome)Target: proteasomein vitro: VR23 is a novel proteasome inhibitor targeting β2 of the 20S proteasome subunit. VR23 produces a synergistic effect in killing multiple myeloma cells, including those that were resistant to bortezomib. VR23 as a structurally novel proteasome inhibitor with desirable properties as an anticancer agent.in vivo: VR23 shows effective antitumor and antiangiogenic activities in mice.

Related Catalog

Signaling Pathways >>Metabolic Enzyme/Protease >>ProteasomeResearch Areas >>Metabolic Disease

References

[1]. Pundir S, et al. VR23: A Quinoline-Sulfonyl Hybrid Proteasome Inhibitor That Selectively Kills Cancer via Cyclin E-Mediated Centrosome Amplification. Cancer Res. 2015 Oct 1;75(19):4164-4175.

[2]. Lee Hoyun, et al. Preparation of quinoline sulfonyl derivatives for the treatment of cancer. From PCT Int. Appl. (2014), WO 2014134705 A1 20140912.

Chemical & Physical Properties

Density	1.6±0.1 g/cm3
Boiling Point	699.3±65.0 °C at 760 mmHg
Molecular Formula	C₁₉H₁₆ClN₅O₆S
Molecular Weight	477.878
Flash Point	376.7±34.3 °C
Exact Mass	477.050995
LogP	3.49
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.697
InChIKey	PDQVZPPIHADUOO-UHFFFAOYSA-N
SMILES	O=[N+]([O-])c1ccc(S(=O)(=O)N2CCN(c3ccnc4cc(Cl)ccc34)CC2)c([N+](=O)[O-])c1
Storage condition	-20℃

Synonyms

7-Chloro-4-{4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl}quinoline

Quinoline, 7-chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]-

VR23

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