CAS 1637735-84-2|FIIN-3
Introduction：Basic information about CAS 1637735-84-2|FIIN-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | FIIN-3 | ||
|---|---|---|---|
| CAS Number | 1637735-84-2 | Molecular Weight | 691.607 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 909.4±65.0 °C at 760 mmHg |
| Molecular Formula | C34H36Cl2N8O4 | Melting Point | / |
| MSDS | / | Flash Point | 503.8±34.3 °C |
Names
| Name | N-[4-({[(2,6-Dichloro-3,5-dimethoxyphenyl)carbamoyl](6-{[4-(4-methyl-1-piperazinyl)phenyl]amino}-4-pyrimidinyl)amino}methyl)phenyl]acrylamide |
|---|---|
| Synonym | More Synonyms |
FIIN-3 BiologicalActivity
| Description | FIIN-3 is an irreversible inhibitor of FGFR with an IC50 of 13.1, 21, 31.4, and 35.3 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively. |
|---|---|
| Related Catalog | Research Areas >>Cancer |
| Target | FGFR1:13.1 nM (IC50) FGFR2:21 nM (IC50) FGFR3:31.4 nM (IC50) FGFR4:35.3 nM (IC50) |
| In Vitro | FIIN-3 potently inhibits both WT FGFRs (EC50 in the 1- to 41-nM range) and the gatekeeper mutant of FGFR2 (EC50 of 64 nM). FIIN-3 also strongly inhibits EGFR, with an EC50 of 43 nM. FIIN-3 shows good potency against gatekeeper mutant V564F; FIIN-3 also is potent against the gatekeeper-plus-1 mutant E565K; FIIN-3 also displays antiproliferative activity (with an EC50 of 135 nM) against Ba/F3 cells transformed by the EGFR vIII fusion protein, which has a WT EGFR kinase domain. FIIN-3 shows even better activity against EGFR mutant L858R (EC50 of 17 nM) and moderate activity, displaying an EC50 of 231 nM, against the EGFR mutant L858R/T790M mutant. In WT FGFR2 Ba/F3 cells, FIIN-3 completely inhibits the FGFR2 autophosphorylation on Tyr656/657 at concentrations as low as 3 nM. In FGFR2 V564M Ba/F3 cells, FIIN-3 is capable of inhibiting the FGFR2 mutant V564M autophosphorylation with partial inhibition at 100 nM and complete inhibition observed at 300 nM[1]. |
| Cell Assay | TEL-FGFR2–transformed Ba/F3 cells are seeded in a 96-well plate and are treated with each concentration of FIIN-3. After 72 h the cells are assessed by MTS tetrazolium assay[1]. |
| References | [1]. Tan L et al. Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc Natl Acad Sci U S A, 2014 Nov 11, 111(45):E4869-77 |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 909.4±65.0 °C at 760 mmHg |
| Molecular Formula | C34H36Cl2N8O4 |
| Molecular Weight | 691.607 |
| Flash Point | 503.8±34.3 °C |
| Exact Mass | 690.223633 |
| LogP | 5.65 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.683 |
| InChIKey | SFLKJNSBBVSPFE-UHFFFAOYSA-N |
| SMILES | C=CC(=O)Nc1ccc(CN(C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c2cc(Nc3ccc(N4CCN(C)CC4)cc3)ncn2)cc1 |
| Storage condition | 2-8℃ |
Synonyms
| N-[4-({[(2,6-Dichloro-3,5-dimethoxyphenyl)carbamoyl](6-{[4-(4-methyl-1-piperazinyl)phenyl]amino}-4-pyrimidinyl)amino}methyl)phenyl]acrylamide |
| 2-Propenamide, N-[4-[[[[(2,6-dichloro-3,5-dimethoxyphenyl)amino]carbonyl][6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]methyl]phenyl]- |
| FIIN-3 |
