Introduction：Basic information about CAS 443683-76-9|Alisol F 24-acetate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Alisol F 24-acetate |
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| CAS Number | 443683-76-9 | Molecular Weight | 530.736 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 634.3±55.0 °C at 760 mmHg |
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| Molecular Formula | C32H50O6 | Melting Point | / |
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| MSDS | / | Flash Point | 195.8±25.0 °C |
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Names
| Name | Alisol F 24-acetate |
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| Synonym | More Synonyms |
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Alisol F 24-acetate BiologicalActivity
| Description | Alisol F 24-acetate is a triterpene compound that can be isolated from the rhizomes of Alisma orientalis. Alisol F 24-acetate inhibits the secretion of HBV surface antigen HBsAg and HBeAg with IC50 values of 7.7 µM and 5.1 µM. Alisol F 24-acetate has proapoptotic activity and can be used for cancer research[1][2]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>InfectionSignaling Pathways >>Anti-infection >>HBV |
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| In Vitro | Alisol F 24-acetate (5、10 和 20 µM；24 h) 在 MCF-7/DOX 细胞中以剂量依赖性方式增加了阿霉素 (Doxorubicin，HY-15142A) 的化学敏感性[2]。 Alisol F 24-acetate (5、10 和 20 µM) 在 MCF-7/DOX 细胞中以剂量依赖性方式增加了阿霉素的积累。Alisol F 24-acetate (10 µM) 在 Caco-2 细胞单层中增加了地高辛 (Digoxin，HY-B1049) 的吸收 (AP-BL)，降低了地高辛的分泌 (BL-AP)[2]。 Cell Viability Assay[2] Cell Line: Caco-2 cells and MCF-7/DOX cells. Concentration: 1, 2, 5, 10, 20, 50 and 100 µM. Incubation Time: 24 h. Result: Significantly inhibited the cell viability (100 µM). Apoptosis Analysis[2] Cell Line: MCF-7/DOX cells. Concentration: 5, 10 and 20 µM. Incubation Time: 0.5, 1, 2, 3 and 4 h. Result: Promoted the doxorubicin-induced apoptosis with time and dose dependent manner. |
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| References | [1]. Jiang ZY, et al. A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis. Planta Med. 2006 Aug;72(10):951-4. [2]. Pan G, et al. Alisol F 24 Acetate Enhances Chemosensitivity and Apoptosis of MCF-7/DOX Cells by Inhibiting P-Glycoprotein-Mediated Drug Efflux. Molecules. 2016 Feb 4;21(2):183. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 634.3±55.0 °C at 760 mmHg |
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| Molecular Formula | C32H50O6 |
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| Molecular Weight | 530.736 |
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| Flash Point | 195.8±25.0 °C |
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| Exact Mass | 530.360718 |
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| LogP | 4.54 |
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| Vapour Pressure | 0.0±4.2 mmHg at 25°C |
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| Index of Refraction | 1.552 |
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| InChIKey | KFWYQAKZMXFEFB-XKFNBYHKSA-N |
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| SMILES | CC(=O)OC(C1CC(C)C2=C3CC(O)C4C5(C)CCC(=O)C(C)(C)C5CCC4(C)C3(C)CC2O1)C(C)(C)O |
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Synonyms
| (8alpha,9beta,11beta,14beta,23S,24R)-24-(Acetyloxy)-16,23-epoxy-11,25-dihydroxy-dammar-13(17)-en-3-one |
| Dammar-13(17)-en-3-one, 24-(acetyloxy)-16,23-epoxy-11,25-dihydroxy-, (8α,9β,11β,14β,16β,23S,24S)- |
| (8α,9β,11β,14β,16β,23S,24S)-11,25-Dihydroxy-3-oxo-16,23-epoxydammar-13(17)-en-24-yl acetate |
