Introduction：Basic information about CAS 1353016-71-3|DBCO-NHS ester, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | DBCO-NHS ester |
|---|
| CAS Number | 1353016-71-3 | Molecular Weight | 402.39900 |
|---|
| Density | 1.43±0.1 g/cm3 | Boiling Point | 670.2±65.0 °C at 760 mmHg |
|---|
| Molecular Formula | C23H18N2O5 | Melting Point | / |
|---|
| MSDS | / | Flash Point | / |
|---|
Names
| Name | Dibenzocyclooctyne-N-hydroxysuccinimidyl ester |
|---|
| Synonym | More Synonyms |
|---|
DBCO-NHS ester BiologicalActivity
| Description | DBCO-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC Linker |
|---|
| Target | Cleavable |
|---|
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
|---|
| References | [1]. Method for identifying potential drug target protein useful for development of antibody drug, and method for producing antibody directed against target protein. WO2018151301A1. |
|---|
Chemical & Physical Properties
| Density | 1.43±0.1 g/cm3 |
|---|
| Boiling Point | 670.2±65.0 °C at 760 mmHg |
|---|
| Molecular Formula | C23H18N2O5 |
|---|
| Molecular Weight | 402.39900 |
|---|
| Exact Mass | 402.12200 |
|---|
| PSA | 83.99000 |
|---|
| LogP | 2.32330 |
|---|
| InChIKey | XCEBOJWFQSQZKR-UHFFFAOYSA-N |
|---|
| SMILES | O=C(CCC(=O)N1Cc2ccccc2C#Cc2ccccc21)ON1C(=O)CCC1=O |
|---|
| Storage condition | 2-8℃ |
|---|
Safety Information
Synonyms
| DBCO-NHS ester |
| Dibenzylcyclooctyne-NHS ester |
| Dibenzocyclooctyne-N-hydroxysuccinimidyl ester |
| DBCO-succinyl N-hydroxysuccinimidyl ester |
| 2,5-dioxopyrrolidin-1-yl 4-(11,12-didehydrodibenzo[b,f]azocin-5(6H)-yl)-4-oxobutanoate |
| 2,5-dioxopyrrolidin-1-yl 4-(didehydrodibenzo[b,f]azocin-5(6H)-yl)-4-oxobutanoate |
