Introduction：Basic information about CAS 1334298-90-6|Itacitinib, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Itacitinib |
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| CAS Number | 1334298-90-6 | Molecular Weight | 553.51400 |
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| Density | 1.57±0.1 g/cm3(Predicted) | Boiling Point | / |
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| Molecular Formula | C26H23F4N9O | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | incb-039110 |
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| Synonym | More Synonyms |
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Itacitinib BiologicalActivity
| Description | Itacitinib is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2; Itacitinib is used in the research of myelofibrosis. |
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| Related Catalog | Signaling Pathways >>Epigenetics >>JAKSignaling Pathways >>JAK/STAT Signaling >>JAKSignaling Pathways >>Stem Cell/Wnt >>JAKResearch Areas >>Cancer |
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| Target | JAK1 |
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| In Vitro | Itacitinib (INCB039110) is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2. Itacitinib is used in the research of myelofibrosis[1]. |
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| References | [1]. Mascarenhas JO, et al. Primary analysis of a phase II open-label trial of INCB039110, a selective JAK1 inhibitor, in patients with myelofibrosis. Haematologica. 2017 Feb;102(2):327-335. |
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Chemical & Physical Properties
| Density | 1.57±0.1 g/cm3(Predicted) |
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| Molecular Formula | C26H23F4N9O |
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| Molecular Weight | 553.51400 |
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| Exact Mass | 553.19600 |
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| PSA | 119.62000 |
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| LogP | 3.47948 |
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| InChIKey | KTBSXLIQKWEBRB-UHFFFAOYSA-N |
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| SMILES | N#CCC1(n2cc(-c3ncnc4[nH]ccc34)cn2)CN(C2CCN(C(=O)c3ccnc(C(F)(F)F)c3F)CC2)C1 |
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| Storage condition | -20℃ |
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Safety Information
Synonyms
| 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-yl)acetonitrile |
| {1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile |
| {1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin3-yl}acetonitrile |
| Itacitinib |
