Introduction：Basic information about CAS 1376614-99-1|ent-Ezetimibe, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ent-Ezetimibe |
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| CAS Number | 1376614-99-1 | Molecular Weight | 409.42500 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C24H21F2NO3 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | ezetimibe |
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| Synonym | More Synonyms |
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ent-Ezetimibe BiologicalActivity
| Description | ent-Ezetimibe (ent-SCH 58235) is the RRS-enantiomer of Ezetimibe. Ezetimibe is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator[1]. |
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| Related Catalog | Research Areas >>Cardiovascular Disease |
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| References | [1]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532. [2]. Yijun Zhu, et al. Efficient and scalable process for the synthesis of antihypercholesterolemic drug ezetimibe. An International Journal for Rapid Communication of Synthetic Organic Chemistry |
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Chemical & Physical Properties
| Molecular Formula | C24H21F2NO3 |
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| Molecular Weight | 409.42500 |
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| Exact Mass | 409.14900 |
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| PSA | 60.77000 |
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| LogP | 4.95330 |
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| InChIKey | OLNTVTPDXPETLC-ZRBLBEILSA-N |
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| SMILES | O=C1C(CCC(O)c2ccc(F)cc2)C(c2ccc(O)cc2)N1c1ccc(F)cc1 |
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Safety Information
Synonyms
| ent-Ezetimibe |
| (3S,4R)-1-(4-Fluorophenyl)-3-[(3R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone |
| Ezetimibe Impurity 1 |
