Introduction：Basic information about CAS 16845-16-2|Eleutheroside B1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Eleutheroside B1 |
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| CAS Number | 16845-16-2 | Molecular Weight | 384.33500 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C17H20O10 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
Eleutheroside B1 BiologicalActivity
| Description | Eleutheroside B1, a coumarin compound, has a wide spectrum of anti-human influenza virus efficacy, with an IC50 value of 64-125 µg/ml. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits the mRNA expression of several chemokine genes and the influenza nucleoprotein (NP) gene, and exhibits low cytotoxicity. Antiviral and anti-inflammatory activities[1]. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>Influenza VirusResearch Areas >>InfectionResearch Areas >>Inflammation/Immunology |
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| In Vitro | Eeutheroside B1 (100 µg/ml; 24 hours) influences mRNA expression of host genes and virus genes in A549 cells[1]. RT-PCR[1] Cell Line: Virus-infected A549 cells Concentration: 100 µg/ml Incubation Time: 24 hours Result: The expression of host genes (MAN2A2, POLR2A) and virus genes (PA, PB1, PB2, HA) were decreased. |
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| References | [1]. Yan W, et al. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation.Int J Mol Med. 2018 Nov;42(5):2776-2792. |
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Chemical & Physical Properties
| Molecular Formula | C17H20O10 |
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| Molecular Weight | 384.33500 |
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| Exact Mass | 384.10600 |
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| PSA | 148.05000 |
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| InChIKey | IKUQEFGEUOOPGY-FMKPUTLISA-N |
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| SMILES | COc1cc2ccc(=O)oc2c(OC)c1OC1OC(CO)C(O)C(O)C1O |
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