CAS 1316215-12-9|Citarinostat

Introduction：Basic information about CAS 1316215-12-9|Citarinostat, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Citarinostat BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Citarinostat
CAS Number	1316215-12-9	Molecular Weight	467.948
Density	1.3±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₂₄H₂₆ClN₅O₃	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	Citarinostat
Synonym	More Synonyms

Citarinostat BiologicalActivity

Description	Citarinostat is a HDAC6 specific inhibitor, with IC50 of 4 nM and 76 nM for HDAC6 and HDAC3, respectively.IC50 value: 4 nM (HDAC6), 76 nM (HDAC3)Target: HDACThe detailed information please refer to WO2015061684A1 and 2015054197A1.
Related Catalog	Research Areas >>Cancer
Target	HDAC6:2.6 nM (IC50) HDAC1:35 nM (IC50) HDAC2:45 nM (IC50) HDAC3:46 nM (IC50) HDAC8:137 nM (IC50) HDAC7:7300 nM (IC50)
References	[1]. Huang P, et al. Selective HDAC inhibition by ACY-241 enhances the activity of paclitaxel in solid tumor models. Oncotarget. 2017 Jan 10;8(2):2694-2707. [2]. From PCT Int. Appl. (2015), WO 2015054197 A1 20150416.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Molecular Formula	C₂₄H₂₆ClN₅O₃
Molecular Weight	467.948
Exact Mass	467.172424
PSA	107.45000
LogP	1.80
Index of Refraction	1.624
InChIKey	VLIUIBXPEDFJRF-UHFFFAOYSA-N
SMILES	O=C(CCCCCCNC(=O)c1cnc(N(c2ccccc2)c2ccccc2Cl)nc1)NO
Storage condition	-20℃

Synonyms

2-[(2-Chlorophenyl)(phenyl)amino]-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide

Citarinostat

2-((2-chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxohepl)pyrimidine-5-carboxamide

5-Pyrimidinecarboxamide, 2-[(2-chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-

2-((2-chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide

ACY-241

UNII:441P620G3P

ACY-241 Avi Tini

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