Introduction：Basic information about CAS 259886-51-6|CUCURBIT(8)URIL, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | CUCURBIT(8)URIL |
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| CAS Number | 259886-51-6 | Molecular Weight | 1329.10 |
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| Density | 2.71 | Boiling Point | / |
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| Molecular Formula | C48H48N32O16 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | cucurbit[8]uril |
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| Synonym | More Synonyms |
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CUCURBIT(8)URIL BiologicalActivity
| Description | Cucurbit[8]uril is a potent, low toxicity and orally active supramolecular inducer of protein heterodimerization. Cucurbit[8]uril induces heterodimerization of methylviologen and naphthalene functionalized proteins. Cucurbit[8]uril can induce energy transfer [1][2]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
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| Target | Protein Heterodimerization[1] |
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| In Vitro | Cucurbit[8]uril (0~20 μM; 48 hours; CHO-K1 cells) makes the relative cell viability dropped marginally to 86%[2]. Cucurbit[8]uril indeed selectively induces the heterodimerization of MV–eYFP with Np–eCFP. Cucurbit[8]uril-induced high energy transfer between the proteins is only observed in the presence of all three supramolecular components, allowing the formation of the ternary complex. In the presence of Cucurbit[8]uril, the unspecific protein assembly induced by the methylviologen is inhibited. The ternary system of Cucurbit[8]uril with methylviologen (MV) and naphthalene (NP) can also be successfully used for the formation of selective protein heterodimers of more hydrophobic proteins. The presence of Cucurbit[8]uril as a host molecule is required to prevent MV induced unspecific dimerization with hydrophobic protein surfaces[1]. Cell Viability Assay[1] Cell Line: CHO-K1 cells Concentration: 0~20 μM Incubation Time: 48 hours Result: At the highest investigated concentration of 20 μM after 48 h, the relative cell viability dropped marginally to 86%. |
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| In Vivo | Cucurbit[8]uril shows a very low toxicity of the in vivo intravenous injection, as well as oral administration studies on mice[2]. |
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| References | [1]. Uhlenheuer DA, et al. Cucurbit[8]uril induced heterodimerization of methylviologen and naphthalene functionalized proteins. Chem Commun (Camb). 2011;47(24):6798-6800. [2]. Uzunova VD, et al. Toxicity of cucurbit[7]uril and cucurbit[8]uril: an exploratory in vitro and in vivo study. Org Biomol Chem. 2010;8(9):2037-2042. |
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Chemical & Physical Properties
| Density | 2.71 |
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| Molecular Formula | C48H48N32O16 |
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| Molecular Weight | 1329.10 |
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| Exact Mass | 1328.39000 |
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| PSA | 376.80000 |
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| Appearance of Characters | solid | white |
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| InChIKey | CONWISUOKHSUDR-UHFFFAOYSA-N |
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| SMILES | O=C1N2CN3C(=O)N4CN5C(=O)N6CN7C(=O)N8CN9C(=O)N%10CN%11C(=O)N%12CN%13C(=O)N%14CN%15C(=O)N%16CN1C1C2N2CN%17C(=O)N(CN%18C(=O)N(CN%19C(=O)N(CN%20C(=O)N(CN%21C(=O)N(CN%22C(=O)N(CN%23C(=O)N(CN1C2=O)C%16C%15%23)C%14C%13%22)C%12C%11%21)C%10C9%20)C8C7%19)C6C5%18)C4C3%17 |
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Safety Information
Synonyms
| CB8 |
| Q[8] |
| curcurbit[8]uril |
| MFCD03456501 |
| cucurbituril[8] |
| CB[8] |
