CAS 25990-10-7|Polygalacturonic acid
| Common Name | Polygalacturonic acid | ||
|---|---|---|---|
| CAS Number | 25990-10-7 | Molecular Weight | 194.139 |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 553.4±50.0 °C at 760 mmHg |
| Molecular Formula | C6H10O7 | Melting Point | / |
| MSDS | USA | Flash Point | 302.6±26.6 °C |
Names
| Name | D-Galacturonic acid |
|---|---|
| Synonym | More Synonyms |
Polygalacturonic acid BiologicalActivity
| Description | Polygalacturonic acid (Galacturonic acid polymer) is transparent colloid, is a major component of the cell wall. Polygalacturonic acid can be used to prepare silver nanoparticles (AgNPs), as an antioxidant and anti-inflammatory that protect cells from destructive effect of elevated ROS and accelerate wound healing. Polygalacturonic acid nanoparticles also displays anti-bacterial activity[1][2]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
| In Vitro | Polygalacturonic acid can be used to format a durable hydrogel, to prolong the effect of drugs. Polygalacturonic acid hydrogel/hyaluronate, conjugated Ibuprofen (HY-78131) for example, prevents epidural fibrosis, the severe scar tissue adhesion of laminectomized male adult rats, and increases the efficiency of local inflammation control and reduces the side-effect of Ibuprofen[1]. Polygalacturonic acid hydrogel/hyaluronate (PGA-HA) (2%, 200 μL; 24 h) shows low cytotoxicity on L929 fibroblasts[1]. Polygalacturonic acid (PGA) preparing (Ag-PGA/HA)-PVA nanoparticles, shows anti-bacterial activity against gram-positive bacterial strains; Bacillus Subtilis and Staphylococcus Aureus, as well as gram-negative bacterial strain; Escherichia Coli[2]. |
| In Vivo | Polygalacturonic acid (external application; 14 d) enhances a quick healing of wound infection in albino rats[2]. Animal Model: Full thickness wound model in albino rats (60-day-old, 180 g)[2] Dosage: Ag-Polygalacturonic acid/hyaluronic acid nanoparticles Administration: Applied on dorsal muscle fascia; cleaned the wound daily with alcohol; for 14 days Result: Resulted no sign of abscess formation or hypertrophic scars both in the early phase; 5th day or in the final phase; 14th day, respectively. Showed significant wound healing from day 8 while treated with (Ag-PGA/HA)-PVA nanofiber and blank (PGA/HA)-PVA nanofiber and induced epithelization on day 14. |
| References | [1]. Lin CY, et al. Ibuprofen-conjugated hyaluronate/polygalacturonic acid hydrogel for the prevention of epidural fibrosis. J Biomater Appl. 2016 May;30(10):1589-600. [2]. El-Aassar MR, et al. Wound healing of nanofiber comprising Polygalacturonic/Hyaluronic acid embedded silver nanoparticles: In-vitro and in-vivo studies. Carbohydr Polym. 2020 Jun 15;238:116175. |
Chemical & Physical Properties
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 553.4±50.0 °C at 760 mmHg |
| Molecular Formula | C6H10O7 |
| Molecular Weight | 194.139 |
| Flash Point | 302.6±26.6 °C |
| Exact Mass | 194.042648 |
| LogP | -1.49 |
| Vapour Pressure | 0.0±3.4 mmHg at 25°C |
| Index of Refraction | 1.592 |
| InChIKey | AEMOLEFTQBMNLQ-UHFFFAOYSA-N |
| SMILES | O=C(O)C1OC(O)C(O)C(O)C1O |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
Articles17
More Articles| Leaf-cutting ant fungi produce cell wall degrading pectinase complexes reminiscent of phytopathogenic fungi. BMC Biol. 8 , 156, (2010) Leaf-cutting (attine) ants use their own fecal material to manure fungus gardens, which consist of leaf material overgrown by hyphal threads of the basidiomycete fungus Leucocoprinus gongylophorus tha... | |
| A colorimetric method to quantify endo-polygalacturonase activity. Enzyme Microb. Technol. 48 , 123-128, (2011) We report a new colorimetric assay to quantify endo-polygalacturonase activity, which hydrolyzes polygalacturonic acid to produce smaller chains of galacturonate. Some of the reported polygalacturonas... | |
| Polygalacturonase Isozymes Produced by Phomopsis cucurbitae in Relation to Postharvest Decay of Cantaloupe Fruit. Phytopathology 87 , 1020-1025, (1997) ABSTRACT Production of polygalacturonase (PG), a cell wall-degrading enzyme, by Phomopsis cucurbitae (latent infection fungus) was studied in relation to different carbon sources and various stages of... |
Synonyms
| DL-Galacturonic acid |
| α-D-Galacturonic acid |
| MFCD00131972 |
| D-Galacturonic acid (9CI) |
| D-Galacturonic acid |
| δ-Galacturonic acid |
