Introduction：Basic information about CAS 1309649-57-7|Biotin-PEG4-azide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Biotin-PEG4-azide |
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| CAS Number | 1309649-57-7 | Molecular Weight | 488.601 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C20H36N6O6S | Melting Point | 104 °C |
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| MSDS | / | Flash Point | / |
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Names
| Name | Biotin-PEG4-Azide |
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| Synonym | More Synonyms |
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Biotin-PEG4-azide BiologicalActivity
| Description | Biotin-PEG4-azide is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | PEGs |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. |
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Chemical & Physical Properties
| Melting Point | 104 °C |
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| Molecular Formula | C20H36N6O6S |
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| Molecular Weight | 488.601 |
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| Exact Mass | 488.241699 |
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| LogP | -1.28 |
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| InChIKey | PVEHVEYAPUNCCP-LNLFQRSKSA-N |
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| SMILES | [N-]=[N+]=NCCOCCOCCOCCOCCNC(=O)CCCCC1SCC2NC(=O)NC21 |
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Synonyms
| N-(14-Azido-3,6,9,12-tetraoxatetradec-1-yl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide |
| MFCD27977501 |
| 1H-Thieno[3,4-d]imidazole-4-pentanamide, N-(14-azido-3,6,9,12-tetraoxatetradec-1-yl)hexahydro-2-oxo-, (3aS,4S,6aR)- |
