CAS 31894-34-5|ζ-Stat trisodium
Introduction：Basic information about CAS 31894-34-5|ζ-Stat trisodium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ζ-Stat trisodium | ||
|---|---|---|---|
| CAS Number | 31894-34-5 | Molecular Weight | 450.31 |
| Density | / | Boiling Point | / |
| Molecular Formula | C10H5Na3O10S3 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | 1-Naphthol-3,6,8-trisulfonic acid trisodium salt |
|---|
ζ-Stat trisodium BiologicalActivity
| Description | ζ-Stat trisodium (NSC37044 trisodium) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat trisodium can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Epigenetics >>PKCSignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>TGF-beta/Smad >>PKC |
| Target | aPKC-ζ:5 μM (IC50) |
| In Vitro | ζ-Stat (0.1-20 µM) shows only 13% inhibition on PKC-ι at 20 μM, but shows a significant inhibition on PKC-ζ as 51% at 5 μM level[1]. ζ-Stat (0.1-10 µM; 3 d) significantly decreases cell proliferation of SK-MEL-2 and MeWo upon increasing the concentrations[1]. ζ-Stat (7 or 10 µM; 24-72 h) and 5-FU in combination is able to decrease the viability of LoVo CRC cells by more than 75%[2]. ζ-Stat (5 µM; 3 d) shows a significant diminution of phosphorylated, total PKC-ζ, Bcl-2 and PARP levels, and increases Caspase-3 and cleaved-PARP levels in SK-MEL-2 and MeWo cells[1]. ζ-Stat (5 µM; 1-10 h) does not show significant cytotoxicity on MEL-F-NEO, SK-MEL-2 and MeWo cells[1]. Cell Proliferation Assay[1] Cell Line: MEL-F-NEO, SK-MEL-2 and MeWo cells Concentration: 0.1, 0.5, 1, 2.5, 5, 7.5, 10 µM Incubation Time: 3 days Result: Decreased proliferation by 47.7% for 5 µM in SK-MEL-2 cells and by 50.6% for 5 µM in MeWo cells. Showed significant inhibitions on MEL-F-NEO cells 19.3% (P ≤ 0.05) at 10 μM. Western Blot Analysis[1] Cell Line: SK-MEL-2 and MeWo cells Concentration: 5 µM Incubation Time: 3 days Result: Decreased phosphorylated and total PKC-ζ levels. |
| References | [1]. Ratnayake WS, et, al. Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors. Cell Adh Migr. 2018; 12(5):447-463. [2]. Islam SMA, et, al. Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells. Biomed Pharmacother. 2020 Jan; 121:109665. |
Chemical & Physical Properties
| Molecular Formula | C10H5Na3O10S3 |
|---|---|
| Molecular Weight | 450.31 |
| InChIKey | VQXXRDCDIFAODW-UHFFFAOYSA-K |
| SMILES | O=S(=O)([O-])c1cc(O)c2c(S(=O)(=O)[O-])cc(S(=O)(=O)[O-])cc2c1.[Na+].[Na+].[Na+] |
