Introduction：Basic information about CAS 136212-91-4|Dermaseptin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dermaseptin |
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| CAS Number | 136212-91-4 | Molecular Weight | 3455.06 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C152H257N43O44S2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Dermaseptin from Phyllomedusa sauvagii |
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| Synonym | More Synonyms |
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Dermaseptin BiologicalActivity
| Description | Dermaseptin, a peptide isolated from frog skin, exhibits potent antimicrobial activity against bacteria, fungi and protozoa. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>BacterialSignaling Pathways >>Anti-infection >>FungalResearch Areas >>InfectionNatural Products >>OthersPeptides |
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| In Vitro | Dermaseptin is a water-soluble, thermostable, and nonhemolytic peptide endowed with highly potent antimicrobial activity against pathogenic fungi at micromolar concentration. Circular dichroism spectra of dermaseptin in hydrophobic media indicated 80% alpha-helical conformation, and predictions of secondary structure suggested that dermaseptin can be configured as an amphiphatic alpha-helix spanning over residues 1-27, a structure that perturbs membrane functions regulating water flux[1]. Dermaseptin exerts a lytic action upon bacteria, protozoa, yeasts, and filamentous fungi at micromolar concentrations. Molecular elements responsible for the exceptional antimicrobial potency of dermaseptin are to be traced to the NH2-terminal alpha-helical amphipathic segment spanning residues 1-18 of the molecule[1]. |
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| References | [1]. Mor A, et al. Isolation, amino acid sequence, and synthesis of dermaseptin, a novel antimicrobial peptide of amphibian skin. Biochemistry. 1991 Sep 10;30(36):8824-30. [2]. Mor A, et al. The NH2-terminal alpha-helical domain 1-18 of dermaseptin is responsible for antimicrobial activity. J Biol Chem. 1994 Jan 21;269(3):1934-9. |
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Chemical & Physical Properties
| Molecular Formula | C152H257N43O44S2 |
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| Molecular Weight | 3455.06 |
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| InChIKey | YFHLIDBAPTWLGU-CTKMSOPVSA-N |
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| SMILES | CCC(C)C(NC(=O)C(NC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C(C)NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(CCSC)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)C(C)N)C(C)O)C(C)O)C(C)O)C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NCC(=O)NC(C(=O)NC(CCC(N)=O)C(=O)O)C(C)O |
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| Storage condition | -20°C |
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Safety Information
| Hazard Codes | Xi |
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| Safety Phrases | 22-24/25 |
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| WGK Germany | 3.0 |
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Synonyms
