Introduction：Basic information about CAS 1351636-18-4|ONO-4059, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ONO-4059 |
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| CAS Number | 1351636-18-4 | Molecular Weight | 454.481 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 672.0±65.0 °C at 760 mmHg |
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| Molecular Formula | C25H22N6O3 | Melting Point | / |
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| MSDS | / | Flash Point | 360.2±34.3 °C |
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Names
| Name | tirabrutinib |
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| Synonym | More Synonyms |
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ONO-4059 BiologicalActivity
| Description | Tirabrutinib (ONO-4059) is a highly selective, orally bioavailable BTK inhibitor with an IC50 of 2.2 nM. |
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| Related Catalog | Signaling Pathways >>Protein Tyrosine Kinase/RTK >>BtkResearch Areas >>Cancer |
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| Target | IC50: 2.2 nM (BTK)[1] |
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| References | [1]. Burger JA. Bruton's tyrosine kinase (BTK) inhibitors in clinical trials. Curr Hematol Malig Rep, 2014 Mar, 9(1):44-9. [2]. Harriet S. Walter et al. A phase 1 clinical trial of the selective BTK inhibitor ONO/GS-4059 in relapsed and refractory mature B-cell malignancies. Blood, 2016 Jan 28, 127(4): 411-419. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 672.0±65.0 °C at 760 mmHg |
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| Molecular Formula | C25H22N6O3 |
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| Molecular Weight | 454.481 |
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| Flash Point | 360.2±34.3 °C |
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| Exact Mass | 454.175354 |
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| LogP | 2.31 |
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| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
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| Index of Refraction | 1.700 |
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| InChIKey | SEJLPXCPMNSRAM-GOSISDBHSA-N |
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| SMILES | CC#CC(=O)N1CCC(n2c(=O)n(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 |
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Synonyms
| tirabrutinib |
| MFCD28386296 |
| 8H-Purin-8-one, 6-amino-7,9-dihydro-9-[(3R)-1-(1-oxo-2-butyn-1-yl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)- |
| UNII:LXG44NDL2T |
| 6-Amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one |
| ONO-BKT |
| ONO-4059 |
