CAS 310456-65-6|IMR-1

Introduction：Basic information about CAS 310456-65-6|IMR-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. IMR-1 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	IMR-1
CAS Number	310456-65-6	Molecular Weight	353.413
Density	1.4±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₁₅H₁₅NO₅S₂	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	Ethyl {2-methoxy-4-[(E)-(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy}acetate
Synonym	More Synonyms

IMR-1 BiologicalActivity

Description	IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μmol/L.target: NotchIC 50: 6 μmol/LIn vitro: IMR-1 prevents the recruitment of Maml1 to the NTC on chromatin, inhibits Notch target gene transcription, and dramatically inhibits tumor growth .A decrease in colony formation of Notch-dependent cell lines is observed upon treatment with IMR-1 when compared with the control (DMSO). In vivo : The reference for intraperitoneal injection is 15 mg/kg. IMR-1 inhibits Notch-dependent somite development in zebrafish.
Related Catalog	Signaling Pathways >>Stem Cell/Wnt >>NotchResearch Areas >>Cancer
References	[1]. Astudillo L et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76(12):3593-603.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Molecular Formula	C₁₅H₁₅NO₅S₂
Molecular Weight	353.413
Exact Mass	353.039154
LogP	1.38
Appearance of Characters	yellow solid
Index of Refraction	1.641
InChIKey	QHPJWPQRZMBKTG-GHXNOFRVSA-N
SMILES	CCOC(=O)COc1ccc(C=C2SC(=S)NC2=O)cc1OC
Storage condition	-20℃

Synonyms

Ethyl {2-methoxy-4-[(E)-(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy}acetate

Acetic acid, 2-[2-methoxy-4-[(E)-(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-, ethyl ester

IMR-1

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