CAS 163254-40-8|DISODIUM FOLINATE
Introduction：Basic information about CAS 163254-40-8|DISODIUM FOLINATE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | DISODIUM FOLINATE | ||
|---|---|---|---|
| CAS Number | 163254-40-8 | Molecular Weight | 517.403 |
| Density | / | Boiling Point | / |
| Molecular Formula | C20H21N7Na2O7 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | UNII:4MXU9LJS4Q |
|---|---|
| Synonym | More Synonyms |
DISODIUM FOLINATE BiologicalActivity
| Description | Folinic acid (Leucovorin) disodium is a biological folic acid and is a forms of vitamin B9. Folinic acid disodium is generally administered along with Methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity. Folinic acid disodium and Sfluorouracil adjuvant chemotherapy shows effective in colon carcinoma[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Antifolate |
| Target | Human Endogenous Metabolite |
| In Vitro | Folinic acid disodium (5, 50 µg/ml; 40 h) significantly reduces % micronucleated binucleated cells (MNBN) (40%-68%) and % aberrant cells (Abs) (36%-77%) in V79 cells that were treated with MTX at five different concentrations 5–100 mg/ml for 6 h[1]. |
| In Vivo | Folinic acid disodium (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following Methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2]. Animal Model: 24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)[2] Dosage: 7.0 mg/kg Administration: Intraperitoneal injection; every second day; for 3 weeks Result: Following MTX administration appears to reverse this growth inhibition. |
| References | [1]. Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397(2): p. 221-8. [2]. Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44. [3]. Francini G, et al. Folinic acid and 5-fluorouracil as adjuvant chemotherapy in colon cancer. Gastroenterology. 1994 Apr;106(4):899-906. |
Chemical & Physical Properties
| Molecular Formula | C20H21N7Na2O7 |
|---|---|
| Molecular Weight | 517.403 |
| Exact Mass | 517.129761 |
| InChIKey | FSDMNNPYPVJNAT-RIWFDJIXSA-L |
| SMILES | Nc1nc2c(c(=O)[nH]1)N(C=O)C(CNc1ccc(C(=O)NC(CCC(=O)[O-])C(=O)[O-])cc1)CN2.[Na+].[Na+] |
Synonyms
| UNII:4MXU9LJS4Q |
| L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, sodium salt (1:2) |
| Disodium (2S)-2-[(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl)methyl]amino}benzoyl)amino]pentanedioate |
| MFCD11618008 |
