CAS 131167-89-0|H-Ile-Lys-Val-Ala-Val-OH trifluoroacetate salt
Introduction：Basic information about CAS 131167-89-0|H-Ile-Lys-Val-Ala-Val-OH trifluoroacetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | H-Ile-Lys-Val-Ala-Val-OH trifluoroacetate salt | ||
|---|---|---|---|
| CAS Number | 131167-89-0 | Molecular Weight | 528.685 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 856.6±65.0 °C at 760 mmHg |
| Molecular Formula | C25H48N6O6 | Melting Point | / |
| MSDS | / | Flash Point | 471.9±34.3 °C |
Names
| Name | Laminin-1 peptide |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | H-Ile-Lys-Val-Ala-Val-OH is one of the most potent active sites of laminin-1. H-Ile-Lys-Val-Ala-Val-OH promotes cell adhesion, neurite outgrowth, and tumor growth. H-Ile-Lys-Val-Ala-Val-OH stimulates BMMSC population growth and proliferation by activating MAPK/ERK1/2 and PI3K/Akt signalling pathways[1][2]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>PI3K/Akt/mTOR >>AktSignaling Pathways >>MAPK/ERK Pathway >>ERKResearch Areas >>Neurological DiseaseSignaling Pathways >>Stem Cell/Wnt >>ERK |
| Target | ERK1 ERK2 Akt |
| In Vitro | H-Ile-Lys-Val-Ala-Val-OH (0-2.5 mM, 0-48 h) 诱导骨髓间充质干细胞(BMMSC)增殖和增殖细胞核抗原(PCNA)合成[2]。 H-Ile-Lys-Val-Ala-Val-OH (5 mM, 24 h) 诱导 BMMSC 细胞周期，使细胞从 G0/G1 进入 S 期并阻止它们进入 G2/M 期[2]。 H-Ile-Lys-Val-Ala-Val-OH (0-2.5 mM, 0-48 h) 通过增强 BMMSCs 中 ERK1/2 和 Akt 的磷酸化水平激活 MAPK/ERK 和 PI3K/Akt 信号通路[2]。 Cell Proliferation Assay[2] Cell Line: BMMSC Concentration: 0, 0.004, 0.02, 0.1, 0.5 and 2.5 mM Incubation Time: 0, 12, 24, 36, 48 h Result: Stimulated proliferating cell nuclear antigen (PCNA) synthesis and induced proliferation of bone marrow mesenchymal stem cell (BMMSC) in a dose- and time-dependent manner. Cell Cycle Analysis[2] Cell Line: BMMSC Concentration: 5 mM Incubation Time: 24 h Result: Induced the BMMSC cell cycle for cells to enter S phase from G0/G1 and arrested them from entering G2/M phase; the increased proportion of S phase in cell cycle was considered to be a sign of BMMSC proliferation. Western Blot Analysis[2] Cell Line: BMMSC Concentration: 0, 0.004, 0.02, 0.1, 0.5 and 2.5 mM Incubation Time: 0, 12, 24, 36, 48 h Result: Increased significantly the levels of p-ERK1/2 and p-Akt in a dose- and time-dependent manner. |
| References | [1]. Nomizu M, et al. The all-D-configuration segment containing the IKVAV sequence of laminin A chain has similar activities to the all-L-peptide in vitro and in vivo. J Biol Chem. 1992 Jul 15;267(20):14118-21. [2]. Li B, et al. IKVAV regulates ERK1/2 and Akt signalling pathways in BMMSC population growth and proliferation. Cell Prolif. 2014 Apr;47(2):133-45. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 856.6±65.0 °C at 760 mmHg |
| Molecular Formula | C25H48N6O6 |
| Molecular Weight | 528.685 |
| Flash Point | 471.9±34.3 °C |
| Exact Mass | 528.363525 |
| LogP | 1.27 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.511 |
| InChIKey | XQQUSYWGKLRJRA-RABCQHRBSA-N |
| SMILES | CCC(C)C(N)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(C)C(=O)NC(C(=O)O)C(C)C)C(C)C |
Synonyms
| L-Isoleucyl-L-lysyl-L-valyl-L-alanyl-L-valine |
| L-Valine, L-isoleucyl-L-lysyl-L-valyl-L-alanyl- |
